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Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults
Accumulating evidence linking trimethylamine N-oxide (TMAO) to cardiovascular disease (CVD) risk has prompted interest in developing therapeutic strategies to reduce its production. We compared two lifestyle intervention approaches: hypocaloric versus eucaloric diet, combined with exercise, on TMAO...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356515/ https://www.ncbi.nlm.nih.gov/pubmed/30654453 http://dx.doi.org/10.3390/nu11010179 |
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author | Erickson, Melissa L. Malin, Steven K. Wang, Zeneng Brown, J. Mark Hazen, Stanley L. Kirwan, John P. |
author_facet | Erickson, Melissa L. Malin, Steven K. Wang, Zeneng Brown, J. Mark Hazen, Stanley L. Kirwan, John P. |
author_sort | Erickson, Melissa L. |
collection | PubMed |
description | Accumulating evidence linking trimethylamine N-oxide (TMAO) to cardiovascular disease (CVD) risk has prompted interest in developing therapeutic strategies to reduce its production. We compared two lifestyle intervention approaches: hypocaloric versus eucaloric diet, combined with exercise, on TMAO levels in relation to CVD risk factors. Sixteen obese adults (66.1 ± 4.4 years, BMI (body mass index): 35.9 ± 5.3 kg/m(2), fasting glucose: 106 ± 16 mg/dL, 2-h PPG (postprandial glucose): 168 ± 37 mg/dL) were randomly assigned to 12 weeks of exercise (5 days/week, 80–85% HR(max) (maximal heart rate)) plus either a hypocaloric (HYPO) (−500 kcal) or a eucaloric (EU) diet. Outcomes included plasma TMAO, glucose metabolism (oral glucose tolerance test (OGTT) and euglycemic-hyperinsulinemic clamps for glucose disposal rates (GDR)), exercise capacity (VO(2max), maximal oxygen consumption), abdominal adiposity (computed tomography scans), cholesterol, and triglycerides. Results showed that body composition (body weight, subcutaneous adiposity), insulin sensitivity, VO(2max), and cholesterol all improved (p < 0.05). HYPO decreased the percentage change in TMAO compared to an increase after EU (HYPO: −31 ± 0.4% vs. EU: 32 ± 0.6%, p = 0.04). Absolute TMAO levels were not impacted (HYPO: p = 0.09 or EU: p = 0.53 group). The change in TMAO after intervention was inversely correlated with baseline visceral adipose tissue (r = −0.63, p = 0.009) and GDR (r = 0.58, p = 0.002). A hypocaloric diet and exercise approach appears to be effective in reducing TMAO. Larger trials are needed to support this observation. |
format | Online Article Text |
id | pubmed-6356515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63565152019-02-01 Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults Erickson, Melissa L. Malin, Steven K. Wang, Zeneng Brown, J. Mark Hazen, Stanley L. Kirwan, John P. Nutrients Article Accumulating evidence linking trimethylamine N-oxide (TMAO) to cardiovascular disease (CVD) risk has prompted interest in developing therapeutic strategies to reduce its production. We compared two lifestyle intervention approaches: hypocaloric versus eucaloric diet, combined with exercise, on TMAO levels in relation to CVD risk factors. Sixteen obese adults (66.1 ± 4.4 years, BMI (body mass index): 35.9 ± 5.3 kg/m(2), fasting glucose: 106 ± 16 mg/dL, 2-h PPG (postprandial glucose): 168 ± 37 mg/dL) were randomly assigned to 12 weeks of exercise (5 days/week, 80–85% HR(max) (maximal heart rate)) plus either a hypocaloric (HYPO) (−500 kcal) or a eucaloric (EU) diet. Outcomes included plasma TMAO, glucose metabolism (oral glucose tolerance test (OGTT) and euglycemic-hyperinsulinemic clamps for glucose disposal rates (GDR)), exercise capacity (VO(2max), maximal oxygen consumption), abdominal adiposity (computed tomography scans), cholesterol, and triglycerides. Results showed that body composition (body weight, subcutaneous adiposity), insulin sensitivity, VO(2max), and cholesterol all improved (p < 0.05). HYPO decreased the percentage change in TMAO compared to an increase after EU (HYPO: −31 ± 0.4% vs. EU: 32 ± 0.6%, p = 0.04). Absolute TMAO levels were not impacted (HYPO: p = 0.09 or EU: p = 0.53 group). The change in TMAO after intervention was inversely correlated with baseline visceral adipose tissue (r = −0.63, p = 0.009) and GDR (r = 0.58, p = 0.002). A hypocaloric diet and exercise approach appears to be effective in reducing TMAO. Larger trials are needed to support this observation. MDPI 2019-01-16 /pmc/articles/PMC6356515/ /pubmed/30654453 http://dx.doi.org/10.3390/nu11010179 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Erickson, Melissa L. Malin, Steven K. Wang, Zeneng Brown, J. Mark Hazen, Stanley L. Kirwan, John P. Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults |
title | Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults |
title_full | Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults |
title_fullStr | Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults |
title_full_unstemmed | Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults |
title_short | Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults |
title_sort | effects of lifestyle intervention on plasma trimethylamine n-oxide in obese adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356515/ https://www.ncbi.nlm.nih.gov/pubmed/30654453 http://dx.doi.org/10.3390/nu11010179 |
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