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Acoustophoretic Control of Microparticle Transport Using Dual-Wavelength Surface Acoustic Wave Devices

We present a numerical and experimental study of acoustophoretic manipulation in a microfluidic channel using dual-wavelength standing surface acoustic waves (SSAWs) to transport microparticles into different outlets. The SSAW fields were excited by interdigital transducers (IDTs) composed of two di...

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Autores principales: Hsu, Jin-Chen, Hsu, Chih-Hsun, Huang, Yeo-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356526/
https://www.ncbi.nlm.nih.gov/pubmed/30642118
http://dx.doi.org/10.3390/mi10010052
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author Hsu, Jin-Chen
Hsu, Chih-Hsun
Huang, Yeo-Wei
author_facet Hsu, Jin-Chen
Hsu, Chih-Hsun
Huang, Yeo-Wei
author_sort Hsu, Jin-Chen
collection PubMed
description We present a numerical and experimental study of acoustophoretic manipulation in a microfluidic channel using dual-wavelength standing surface acoustic waves (SSAWs) to transport microparticles into different outlets. The SSAW fields were excited by interdigital transducers (IDTs) composed of two different pitches connected in parallel and series on a lithium niobate substrate such that it yielded spatially superimposed and separated dual-wavelength SSAWs, respectively. SSAWs of a singltablee target wavelength can be efficiently excited by giving an RF voltage of frequency determined by the ratio of the velocity of the SAW to the target IDT pitch (i.e., f = c(SAW)/p). However, the two-pitch IDTs with similar pitches excite, less efficiently, non-target SSAWs with the wavelength associated with the non-target pitch in addition to target SSAWs by giving the target single-frequency RF voltage. As a result, dual-wavelength SSAWs can be formed. Simulated results revealed variations of acoustic pressure fields induced by the dual-wavelength SSAWs and corresponding influences on the particle motion. The acoustic radiation force in the acoustic pressure field was calculated to pinpoint zero-force positions and simulate particle motion trajectories. Then, dual-wavelength SSAW acoustofluidic devices were fabricated in accordance with the simulation results to experimentally demonstrate switching of SSAW fields as a means of transporting particles. The effects of non-target SSAWs on pre-actuating particles were predicted and observed. The study provides the design considerations needed for the fabrication of acoustofluidic devices with IDT-excited multi-wavelength SSAWs for acoustophoresis of microparticles.
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spelling pubmed-63565262019-02-05 Acoustophoretic Control of Microparticle Transport Using Dual-Wavelength Surface Acoustic Wave Devices Hsu, Jin-Chen Hsu, Chih-Hsun Huang, Yeo-Wei Micromachines (Basel) Article We present a numerical and experimental study of acoustophoretic manipulation in a microfluidic channel using dual-wavelength standing surface acoustic waves (SSAWs) to transport microparticles into different outlets. The SSAW fields were excited by interdigital transducers (IDTs) composed of two different pitches connected in parallel and series on a lithium niobate substrate such that it yielded spatially superimposed and separated dual-wavelength SSAWs, respectively. SSAWs of a singltablee target wavelength can be efficiently excited by giving an RF voltage of frequency determined by the ratio of the velocity of the SAW to the target IDT pitch (i.e., f = c(SAW)/p). However, the two-pitch IDTs with similar pitches excite, less efficiently, non-target SSAWs with the wavelength associated with the non-target pitch in addition to target SSAWs by giving the target single-frequency RF voltage. As a result, dual-wavelength SSAWs can be formed. Simulated results revealed variations of acoustic pressure fields induced by the dual-wavelength SSAWs and corresponding influences on the particle motion. The acoustic radiation force in the acoustic pressure field was calculated to pinpoint zero-force positions and simulate particle motion trajectories. Then, dual-wavelength SSAW acoustofluidic devices were fabricated in accordance with the simulation results to experimentally demonstrate switching of SSAW fields as a means of transporting particles. The effects of non-target SSAWs on pre-actuating particles were predicted and observed. The study provides the design considerations needed for the fabrication of acoustofluidic devices with IDT-excited multi-wavelength SSAWs for acoustophoresis of microparticles. MDPI 2019-01-13 /pmc/articles/PMC6356526/ /pubmed/30642118 http://dx.doi.org/10.3390/mi10010052 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsu, Jin-Chen
Hsu, Chih-Hsun
Huang, Yeo-Wei
Acoustophoretic Control of Microparticle Transport Using Dual-Wavelength Surface Acoustic Wave Devices
title Acoustophoretic Control of Microparticle Transport Using Dual-Wavelength Surface Acoustic Wave Devices
title_full Acoustophoretic Control of Microparticle Transport Using Dual-Wavelength Surface Acoustic Wave Devices
title_fullStr Acoustophoretic Control of Microparticle Transport Using Dual-Wavelength Surface Acoustic Wave Devices
title_full_unstemmed Acoustophoretic Control of Microparticle Transport Using Dual-Wavelength Surface Acoustic Wave Devices
title_short Acoustophoretic Control of Microparticle Transport Using Dual-Wavelength Surface Acoustic Wave Devices
title_sort acoustophoretic control of microparticle transport using dual-wavelength surface acoustic wave devices
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356526/
https://www.ncbi.nlm.nih.gov/pubmed/30642118
http://dx.doi.org/10.3390/mi10010052
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