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Laser-Inscribed Glass Microfluidic Device for Non-Mixing Flow of Miscible Solvents
In recent years, there has been significant research on integrated microfluidic devices. Microfluidics offer an advantageous platform for the parallel laminar flow of adjacent solvents of potential use in modern chemistry and biology. To reach that aim, we worked towards the realization of a buried...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356550/ https://www.ncbi.nlm.nih.gov/pubmed/30597992 http://dx.doi.org/10.3390/mi10010023 |
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author | Italia, Valeria Giakoumaki, Argyro N. Bonfadini, Silvio Bharadwaj, Vibhav Le Phu, Thien Eaton, Shane M. Ramponi, Roberta Bergamini, Giacomo Lanzani, Guglielmo Criante, Luigino |
author_facet | Italia, Valeria Giakoumaki, Argyro N. Bonfadini, Silvio Bharadwaj, Vibhav Le Phu, Thien Eaton, Shane M. Ramponi, Roberta Bergamini, Giacomo Lanzani, Guglielmo Criante, Luigino |
author_sort | Italia, Valeria |
collection | PubMed |
description | In recent years, there has been significant research on integrated microfluidic devices. Microfluidics offer an advantageous platform for the parallel laminar flow of adjacent solvents of potential use in modern chemistry and biology. To reach that aim, we worked towards the realization of a buried microfluidic Lab-on-a-Chip which enables the separation of the two components by exploiting the non-mixing properties of laminar flow. To fabricate the aforementioned chip, we employed a femtosecond laser irradiation technique followed by chemical etching. To optimize the configuration of the chip, several geometrical and structural parameters were taken into account. The diffusive mass transfer between the two fluids was estimated and the optimal chip configuration for low diffusion rate of the components was defined. |
format | Online Article Text |
id | pubmed-6356550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63565502019-02-05 Laser-Inscribed Glass Microfluidic Device for Non-Mixing Flow of Miscible Solvents Italia, Valeria Giakoumaki, Argyro N. Bonfadini, Silvio Bharadwaj, Vibhav Le Phu, Thien Eaton, Shane M. Ramponi, Roberta Bergamini, Giacomo Lanzani, Guglielmo Criante, Luigino Micromachines (Basel) Article In recent years, there has been significant research on integrated microfluidic devices. Microfluidics offer an advantageous platform for the parallel laminar flow of adjacent solvents of potential use in modern chemistry and biology. To reach that aim, we worked towards the realization of a buried microfluidic Lab-on-a-Chip which enables the separation of the two components by exploiting the non-mixing properties of laminar flow. To fabricate the aforementioned chip, we employed a femtosecond laser irradiation technique followed by chemical etching. To optimize the configuration of the chip, several geometrical and structural parameters were taken into account. The diffusive mass transfer between the two fluids was estimated and the optimal chip configuration for low diffusion rate of the components was defined. MDPI 2018-12-29 /pmc/articles/PMC6356550/ /pubmed/30597992 http://dx.doi.org/10.3390/mi10010023 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Italia, Valeria Giakoumaki, Argyro N. Bonfadini, Silvio Bharadwaj, Vibhav Le Phu, Thien Eaton, Shane M. Ramponi, Roberta Bergamini, Giacomo Lanzani, Guglielmo Criante, Luigino Laser-Inscribed Glass Microfluidic Device for Non-Mixing Flow of Miscible Solvents |
title | Laser-Inscribed Glass Microfluidic Device for Non-Mixing Flow of Miscible Solvents |
title_full | Laser-Inscribed Glass Microfluidic Device for Non-Mixing Flow of Miscible Solvents |
title_fullStr | Laser-Inscribed Glass Microfluidic Device for Non-Mixing Flow of Miscible Solvents |
title_full_unstemmed | Laser-Inscribed Glass Microfluidic Device for Non-Mixing Flow of Miscible Solvents |
title_short | Laser-Inscribed Glass Microfluidic Device for Non-Mixing Flow of Miscible Solvents |
title_sort | laser-inscribed glass microfluidic device for non-mixing flow of miscible solvents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356550/ https://www.ncbi.nlm.nih.gov/pubmed/30597992 http://dx.doi.org/10.3390/mi10010023 |
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