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Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations

Ample evidence from epidemiological studies has linked maternal obesity with metabolic disorders such as obesity, cardiovascular disease, and diabetes in the next generation. Recently, it was also shown that maternal obesity has long-term effects on the progeny’s central nervous system. However, ver...

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Autores principales: Sarker, Gitalee, Peleg-Raibstein, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356622/
https://www.ncbi.nlm.nih.gov/pubmed/30577472
http://dx.doi.org/10.3390/nu11010007
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author Sarker, Gitalee
Peleg-Raibstein, Daria
author_facet Sarker, Gitalee
Peleg-Raibstein, Daria
author_sort Sarker, Gitalee
collection PubMed
description Ample evidence from epidemiological studies has linked maternal obesity with metabolic disorders such as obesity, cardiovascular disease, and diabetes in the next generation. Recently, it was also shown that maternal obesity has long-term effects on the progeny’s central nervous system. However, very little is known regarding how maternal overnutrition may affect, in particular, the cognitive abilities of the offspring. We reported that first-generation offspring exposed to a maternal high-fat diet (MHFD) displayed age-dependent cognitive deficits. These deficits were associated with attenuations of amino acid levels in the medial prefrontal cortex and the hippocampus regions of MHFD offspring. Here, we tested the hypothesis that MHFD in mice may induce long-term cognitive impairments and neurochemical dysfunctions in the second and third generations. We found that MHFD led to cognitive disabilities and an altered response to a noncompetitive receptor antagonist of the N-Methyl-D-aspartic acid (NMDA) receptor in adult MHFD offspring in both second and third generations in a sex-specific manner. Our results suggest that maternal overnutrition leads to an increased risk of developing obesity in subsequent generations as well as to cognitive impairments, affecting learning and memory processes in adulthood. Furthermore, MHFD exposure may facilitate pathological brain aging which is not a consequence of obesity. Our findings shed light on the long-term effects of maternal overnutrition on the development of the central nervous system and the underlying mechanisms which these traits relate to disease predisposition.
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spelling pubmed-63566222019-02-01 Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations Sarker, Gitalee Peleg-Raibstein, Daria Nutrients Article Ample evidence from epidemiological studies has linked maternal obesity with metabolic disorders such as obesity, cardiovascular disease, and diabetes in the next generation. Recently, it was also shown that maternal obesity has long-term effects on the progeny’s central nervous system. However, very little is known regarding how maternal overnutrition may affect, in particular, the cognitive abilities of the offspring. We reported that first-generation offspring exposed to a maternal high-fat diet (MHFD) displayed age-dependent cognitive deficits. These deficits were associated with attenuations of amino acid levels in the medial prefrontal cortex and the hippocampus regions of MHFD offspring. Here, we tested the hypothesis that MHFD in mice may induce long-term cognitive impairments and neurochemical dysfunctions in the second and third generations. We found that MHFD led to cognitive disabilities and an altered response to a noncompetitive receptor antagonist of the N-Methyl-D-aspartic acid (NMDA) receptor in adult MHFD offspring in both second and third generations in a sex-specific manner. Our results suggest that maternal overnutrition leads to an increased risk of developing obesity in subsequent generations as well as to cognitive impairments, affecting learning and memory processes in adulthood. Furthermore, MHFD exposure may facilitate pathological brain aging which is not a consequence of obesity. Our findings shed light on the long-term effects of maternal overnutrition on the development of the central nervous system and the underlying mechanisms which these traits relate to disease predisposition. MDPI 2018-12-20 /pmc/articles/PMC6356622/ /pubmed/30577472 http://dx.doi.org/10.3390/nu11010007 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sarker, Gitalee
Peleg-Raibstein, Daria
Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations
title Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations
title_full Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations
title_fullStr Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations
title_full_unstemmed Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations
title_short Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations
title_sort maternal overnutrition induces long-term cognitive deficits across several generations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356622/
https://www.ncbi.nlm.nih.gov/pubmed/30577472
http://dx.doi.org/10.3390/nu11010007
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