Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus

Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry a...

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Detalles Bibliográficos
Autores principales: Batista, Mariana N., Braga, Ana Cláudia S., Campos, Guilherme Rodrigues Fernandes, Souza, Marcos Michel, de Matos, Renata Prandini Adum, Lopes, Tairine Zara, Candido, Natalia Maria, Lima, Maria Leticia Duarte, Machado, Francielly Cristina, de Andrade, Stephane Tereza Queiroz, Bittar, Cíntia, Nogueira, Maurício L., Carneiro, Bruno M., Mariutti, Ricardo B., Arni, Raghuvir Krishnaswamy, Calmon, Marilia Freitas, Rahal, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356660/
https://www.ncbi.nlm.nih.gov/pubmed/30641880
http://dx.doi.org/10.3390/v11010049
Descripción
Sumario:Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 µM), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus.

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