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Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon
Bothrops snakebites usually present systemic bleeding, and the clinical–epidemiological and laboratorial factors associated with the development of this manifestation are not well established. In this study, we assessed the prevalence of Bothrops snakebites with systemic bleeding reported at the Fun...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356762/ https://www.ncbi.nlm.nih.gov/pubmed/30621001 http://dx.doi.org/10.3390/toxins11010022 |
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author | Oliveira, Sâmella S. Alves, Eliane C. Santos, Alessandra S. Pereira, João Pedro T. Sarraff, Lybia Kássia S. Nascimento, Elizandra F. de-Brito-Sousa, José Diego Sampaio, Vanderson S. Lacerda, Marcus V.G. Sachett, Jacqueline A.G. Sano-Martins, Ida S. Monteiro, Wuelton M. |
author_facet | Oliveira, Sâmella S. Alves, Eliane C. Santos, Alessandra S. Pereira, João Pedro T. Sarraff, Lybia Kássia S. Nascimento, Elizandra F. de-Brito-Sousa, José Diego Sampaio, Vanderson S. Lacerda, Marcus V.G. Sachett, Jacqueline A.G. Sano-Martins, Ida S. Monteiro, Wuelton M. |
author_sort | Oliveira, Sâmella S. |
collection | PubMed |
description | Bothrops snakebites usually present systemic bleeding, and the clinical–epidemiological and laboratorial factors associated with the development of this manifestation are not well established. In this study, we assessed the prevalence of Bothrops snakebites with systemic bleeding reported at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, in Manaus, Amazonas State, Brazil, and the clinical–epidemiological and laboratorial factors associated with systemic bleeding. This is an observational, cross-sectional study carried out between August, 2013 and July, 2016. Patients who developed systemic bleeding on admission or during hospitalization were considered cases, and those with non-systemic bleeding were included in the control group. Systemic bleeding was observed in 63 (15.3%) of the 442 Bothrops snakebites evaluated. Bothrops snakebites mostly occurred in males (78.2%), in rural areas (89.0%) and in the age group of 11 to 30 years old (40.4%). It took most of the patients (59.8%) less than 3 h to receive medical assistance. Unclottable blood (AOR = 3.11 (95% CI = 1.53 to 6.31; p = 0.002)) and thrombocytopenia (AOR = 4.52 (95% CI = 2.03 to 10.09; p < 0.001)) on admission were independently associated with systemic bleeding during hospitalization. These hemostatic disorders on admission increase the chances of systemic bleeding during hospitalization. Prospective studies are needed to clarify the pathophysiology of systemic bleeding in Bothrops snakebites in the Amazon region. |
format | Online Article Text |
id | pubmed-6356762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63567622019-02-05 Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon Oliveira, Sâmella S. Alves, Eliane C. Santos, Alessandra S. Pereira, João Pedro T. Sarraff, Lybia Kássia S. Nascimento, Elizandra F. de-Brito-Sousa, José Diego Sampaio, Vanderson S. Lacerda, Marcus V.G. Sachett, Jacqueline A.G. Sano-Martins, Ida S. Monteiro, Wuelton M. Toxins (Basel) Article Bothrops snakebites usually present systemic bleeding, and the clinical–epidemiological and laboratorial factors associated with the development of this manifestation are not well established. In this study, we assessed the prevalence of Bothrops snakebites with systemic bleeding reported at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, in Manaus, Amazonas State, Brazil, and the clinical–epidemiological and laboratorial factors associated with systemic bleeding. This is an observational, cross-sectional study carried out between August, 2013 and July, 2016. Patients who developed systemic bleeding on admission or during hospitalization were considered cases, and those with non-systemic bleeding were included in the control group. Systemic bleeding was observed in 63 (15.3%) of the 442 Bothrops snakebites evaluated. Bothrops snakebites mostly occurred in males (78.2%), in rural areas (89.0%) and in the age group of 11 to 30 years old (40.4%). It took most of the patients (59.8%) less than 3 h to receive medical assistance. Unclottable blood (AOR = 3.11 (95% CI = 1.53 to 6.31; p = 0.002)) and thrombocytopenia (AOR = 4.52 (95% CI = 2.03 to 10.09; p < 0.001)) on admission were independently associated with systemic bleeding during hospitalization. These hemostatic disorders on admission increase the chances of systemic bleeding during hospitalization. Prospective studies are needed to clarify the pathophysiology of systemic bleeding in Bothrops snakebites in the Amazon region. MDPI 2019-01-07 /pmc/articles/PMC6356762/ /pubmed/30621001 http://dx.doi.org/10.3390/toxins11010022 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Oliveira, Sâmella S. Alves, Eliane C. Santos, Alessandra S. Pereira, João Pedro T. Sarraff, Lybia Kássia S. Nascimento, Elizandra F. de-Brito-Sousa, José Diego Sampaio, Vanderson S. Lacerda, Marcus V.G. Sachett, Jacqueline A.G. Sano-Martins, Ida S. Monteiro, Wuelton M. Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon |
title | Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon |
title_full | Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon |
title_fullStr | Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon |
title_full_unstemmed | Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon |
title_short | Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon |
title_sort | factors associated with systemic bleeding in bothrops envenomation in a tertiary hospital in the brazilian amazon |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356762/ https://www.ncbi.nlm.nih.gov/pubmed/30621001 http://dx.doi.org/10.3390/toxins11010022 |
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