Circulating Biomarkers for Prediction of Objective Response to Chemotherapy in Pancreatic Cancer Patients

Pancreatic cancer is a lethal disease with increasing incidence. Most patients present with advanced disease, for which palliative systemic chemotherapy is the only therapeutic option. Despite improved median survival rates with FOLFIRINOX or gemcitabine chemotherapy compared to the best supportive...

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Autores principales: van der Sijde, Fleur, Vietsch, Eveline E., Mustafa, Dana A. M., Besselink, Marc G., Groot Koerkamp, Bas, van Eijck, Casper H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356815/
https://www.ncbi.nlm.nih.gov/pubmed/30650521
http://dx.doi.org/10.3390/cancers11010093
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author van der Sijde, Fleur
Vietsch, Eveline E.
Mustafa, Dana A. M.
Besselink, Marc G.
Groot Koerkamp, Bas
van Eijck, Casper H. J.
author_facet van der Sijde, Fleur
Vietsch, Eveline E.
Mustafa, Dana A. M.
Besselink, Marc G.
Groot Koerkamp, Bas
van Eijck, Casper H. J.
author_sort van der Sijde, Fleur
collection PubMed
description Pancreatic cancer is a lethal disease with increasing incidence. Most patients present with advanced disease, for which palliative systemic chemotherapy is the only therapeutic option. Despite improved median survival rates with FOLFIRINOX or gemcitabine chemotherapy compared to the best supportive care, many individual patients may not benefit from chemotherapy. Biomarkers are needed to predict who will benefit from chemotherapy and to monitor a patient’s response to chemotherapy. This review summarizes current research and future perspectives on circulating biomarkers for systemic chemotherapy response.
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spelling pubmed-63568152019-02-05 Circulating Biomarkers for Prediction of Objective Response to Chemotherapy in Pancreatic Cancer Patients van der Sijde, Fleur Vietsch, Eveline E. Mustafa, Dana A. M. Besselink, Marc G. Groot Koerkamp, Bas van Eijck, Casper H. J. Cancers (Basel) Review Pancreatic cancer is a lethal disease with increasing incidence. Most patients present with advanced disease, for which palliative systemic chemotherapy is the only therapeutic option. Despite improved median survival rates with FOLFIRINOX or gemcitabine chemotherapy compared to the best supportive care, many individual patients may not benefit from chemotherapy. Biomarkers are needed to predict who will benefit from chemotherapy and to monitor a patient’s response to chemotherapy. This review summarizes current research and future perspectives on circulating biomarkers for systemic chemotherapy response. MDPI 2019-01-15 /pmc/articles/PMC6356815/ /pubmed/30650521 http://dx.doi.org/10.3390/cancers11010093 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
van der Sijde, Fleur
Vietsch, Eveline E.
Mustafa, Dana A. M.
Besselink, Marc G.
Groot Koerkamp, Bas
van Eijck, Casper H. J.
Circulating Biomarkers for Prediction of Objective Response to Chemotherapy in Pancreatic Cancer Patients
title Circulating Biomarkers for Prediction of Objective Response to Chemotherapy in Pancreatic Cancer Patients
title_full Circulating Biomarkers for Prediction of Objective Response to Chemotherapy in Pancreatic Cancer Patients
title_fullStr Circulating Biomarkers for Prediction of Objective Response to Chemotherapy in Pancreatic Cancer Patients
title_full_unstemmed Circulating Biomarkers for Prediction of Objective Response to Chemotherapy in Pancreatic Cancer Patients
title_short Circulating Biomarkers for Prediction of Objective Response to Chemotherapy in Pancreatic Cancer Patients
title_sort circulating biomarkers for prediction of objective response to chemotherapy in pancreatic cancer patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356815/
https://www.ncbi.nlm.nih.gov/pubmed/30650521
http://dx.doi.org/10.3390/cancers11010093
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