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Appetite and Gastrointestinal Hormone Response to a Gluten-Free Meal in Patients with Coeliac Disease

Coeliac disease (CeD) is an immune-mediated inflammatory enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gastrointestinal (GI) hormone response related to appetite and glucose metabolism is still under-investigated in patients with CeD. This study aimed at sh...

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Autores principales: Vitaglione, Paola, Zingone, Fabiana, Virgilio, Nicolina, Ciacci, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356816/
https://www.ncbi.nlm.nih.gov/pubmed/30609862
http://dx.doi.org/10.3390/nu11010082
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author Vitaglione, Paola
Zingone, Fabiana
Virgilio, Nicolina
Ciacci, Carolina
author_facet Vitaglione, Paola
Zingone, Fabiana
Virgilio, Nicolina
Ciacci, Carolina
author_sort Vitaglione, Paola
collection PubMed
description Coeliac disease (CeD) is an immune-mediated inflammatory enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gastrointestinal (GI) hormone response related to appetite and glucose metabolism is still under-investigated in patients with CeD. This study aimed at shedding light on the appetite sensations, glycaemia and hormone response induced by a complex meal in patients with coeliac disease. Twenty-two women with CeD, nine at the diagnosis (CeDD) and thirteen under a gluten-free diet (CeDGF), and ten healthy subjects (HS) were enrolled in a single day intervention study. All subjects consumed a test meal, recorded their appetite sensations, and blood was collected over three hours after meal consumption. The study found a lower decrease in hunger in CeDD compared to CeDGF and HS after meal intake. Data showed no difference of fullness and satiety between the groups. CeDD had lower insulin and glucose-dependent insulinotropic polypeptide (GIP) than CeDGF and HS. Both CeDD and CeDGF experienced a lower post-prandial response of glucose than HS. Data suggested that patients with CeD have an impaired glucose absorption after more than 12 months of gluten-free diet. Postprandial GIP may play a significant role in appetite cues and insulin response to a complex meal.
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spelling pubmed-63568162019-02-01 Appetite and Gastrointestinal Hormone Response to a Gluten-Free Meal in Patients with Coeliac Disease Vitaglione, Paola Zingone, Fabiana Virgilio, Nicolina Ciacci, Carolina Nutrients Article Coeliac disease (CeD) is an immune-mediated inflammatory enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gastrointestinal (GI) hormone response related to appetite and glucose metabolism is still under-investigated in patients with CeD. This study aimed at shedding light on the appetite sensations, glycaemia and hormone response induced by a complex meal in patients with coeliac disease. Twenty-two women with CeD, nine at the diagnosis (CeDD) and thirteen under a gluten-free diet (CeDGF), and ten healthy subjects (HS) were enrolled in a single day intervention study. All subjects consumed a test meal, recorded their appetite sensations, and blood was collected over three hours after meal consumption. The study found a lower decrease in hunger in CeDD compared to CeDGF and HS after meal intake. Data showed no difference of fullness and satiety between the groups. CeDD had lower insulin and glucose-dependent insulinotropic polypeptide (GIP) than CeDGF and HS. Both CeDD and CeDGF experienced a lower post-prandial response of glucose than HS. Data suggested that patients with CeD have an impaired glucose absorption after more than 12 months of gluten-free diet. Postprandial GIP may play a significant role in appetite cues and insulin response to a complex meal. MDPI 2019-01-03 /pmc/articles/PMC6356816/ /pubmed/30609862 http://dx.doi.org/10.3390/nu11010082 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vitaglione, Paola
Zingone, Fabiana
Virgilio, Nicolina
Ciacci, Carolina
Appetite and Gastrointestinal Hormone Response to a Gluten-Free Meal in Patients with Coeliac Disease
title Appetite and Gastrointestinal Hormone Response to a Gluten-Free Meal in Patients with Coeliac Disease
title_full Appetite and Gastrointestinal Hormone Response to a Gluten-Free Meal in Patients with Coeliac Disease
title_fullStr Appetite and Gastrointestinal Hormone Response to a Gluten-Free Meal in Patients with Coeliac Disease
title_full_unstemmed Appetite and Gastrointestinal Hormone Response to a Gluten-Free Meal in Patients with Coeliac Disease
title_short Appetite and Gastrointestinal Hormone Response to a Gluten-Free Meal in Patients with Coeliac Disease
title_sort appetite and gastrointestinal hormone response to a gluten-free meal in patients with coeliac disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356816/
https://www.ncbi.nlm.nih.gov/pubmed/30609862
http://dx.doi.org/10.3390/nu11010082
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