The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw

Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salm...

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Autores principales: Lee, Deok-Won, Hyun, Hoon, Lee, Sungsu, Kim, So Yeon, Kim, Gyu-Tae, Um, Sewook, Hong, Sung Ok, Chun, Heung Jae, Yang, Dae Hyeok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356836/
https://www.ncbi.nlm.nih.gov/pubmed/30641942
http://dx.doi.org/10.3390/md17010051
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author Lee, Deok-Won
Hyun, Hoon
Lee, Sungsu
Kim, So Yeon
Kim, Gyu-Tae
Um, Sewook
Hong, Sung Ok
Chun, Heung Jae
Yang, Dae Hyeok
author_facet Lee, Deok-Won
Hyun, Hoon
Lee, Sungsu
Kim, So Yeon
Kim, Gyu-Tae
Um, Sewook
Hong, Sung Ok
Chun, Heung Jae
Yang, Dae Hyeok
author_sort Lee, Deok-Won
collection PubMed
description Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salmon sperm for the treatment of BRONJ, in a BRONJ-induced rat model. Compared with BRONJ-induced samples, PDRN-treated samples exhibited lower necrotic bone percentages and increased numbers of blood vessels and attached osteoclast production. Moreover, local administration of PDRN at a high concentration (8 mg/kg) remarkably resolved the osteonecrosis. Findings from this study suggest that local administration of PDRN at a specific concentration may be considered clinically for the management of BRONJ.
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spelling pubmed-63568362019-02-05 The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw Lee, Deok-Won Hyun, Hoon Lee, Sungsu Kim, So Yeon Kim, Gyu-Tae Um, Sewook Hong, Sung Ok Chun, Heung Jae Yang, Dae Hyeok Mar Drugs Article Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salmon sperm for the treatment of BRONJ, in a BRONJ-induced rat model. Compared with BRONJ-induced samples, PDRN-treated samples exhibited lower necrotic bone percentages and increased numbers of blood vessels and attached osteoclast production. Moreover, local administration of PDRN at a high concentration (8 mg/kg) remarkably resolved the osteonecrosis. Findings from this study suggest that local administration of PDRN at a specific concentration may be considered clinically for the management of BRONJ. MDPI 2019-01-11 /pmc/articles/PMC6356836/ /pubmed/30641942 http://dx.doi.org/10.3390/md17010051 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Deok-Won
Hyun, Hoon
Lee, Sungsu
Kim, So Yeon
Kim, Gyu-Tae
Um, Sewook
Hong, Sung Ok
Chun, Heung Jae
Yang, Dae Hyeok
The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw
title The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw
title_full The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw
title_fullStr The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw
title_full_unstemmed The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw
title_short The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw
title_sort effect of polydeoxyribonucleotide extracted from salmon sperm on the restoration of bisphosphonate-related osteonecrosis of the jaw
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356836/
https://www.ncbi.nlm.nih.gov/pubmed/30641942
http://dx.doi.org/10.3390/md17010051
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