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Multimeric Rhodamine Dye-Induced Aggregation of Silver Nanoparticles for Surface-Enhanced Raman Scattering

[Image: see text] Isotopic variants of Rhodamine 6G (R6G) have previously been used as a method of multiplexed detection for Surface Enhanced Raman Spectroscopy (SERS), including protein detection and quantification. Challenges exist, however, with producing long-term stable SERS signals with exposu...

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Autores principales: Bartolowits, Matthew D., Xin, Meiguo, Petrov, Dino P., Tague, Thomas J., Davisson, Vincent Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356857/
https://www.ncbi.nlm.nih.gov/pubmed/30729221
http://dx.doi.org/10.1021/acsomega.8b02970
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author Bartolowits, Matthew D.
Xin, Meiguo
Petrov, Dino P.
Tague, Thomas J.
Davisson, Vincent Jo
author_facet Bartolowits, Matthew D.
Xin, Meiguo
Petrov, Dino P.
Tague, Thomas J.
Davisson, Vincent Jo
author_sort Bartolowits, Matthew D.
collection PubMed
description [Image: see text] Isotopic variants of Rhodamine 6G (R6G) have previously been used as a method of multiplexed detection for Surface Enhanced Raman Spectroscopy (SERS), including protein detection and quantification. Challenges exist, however, with producing long-term stable SERS signals with exposure to silver or gold metal surfaces without the use of additional protective coatings of nanomaterials. Here, novel rhodamine “dimers” and “trimers” have been created that demonstrate a higher avidity for metal nanoparticles and induce aggregation to create plasmonic “hotspots” as indicated by enhanced Raman scattering in situ. These aggregates can be formed in a colloid, on surfaces, or membrane substrates such as poly(vinylidene fluoride) for applications in biosciences. The integrity of the materials and Raman signals are maintained for months of time on different substrates. These dye materials should provide avenues for simplified in situ generation of sensors for Raman-based assays especially in settings requiring highly robust performance.
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spelling pubmed-63568572019-02-04 Multimeric Rhodamine Dye-Induced Aggregation of Silver Nanoparticles for Surface-Enhanced Raman Scattering Bartolowits, Matthew D. Xin, Meiguo Petrov, Dino P. Tague, Thomas J. Davisson, Vincent Jo ACS Omega [Image: see text] Isotopic variants of Rhodamine 6G (R6G) have previously been used as a method of multiplexed detection for Surface Enhanced Raman Spectroscopy (SERS), including protein detection and quantification. Challenges exist, however, with producing long-term stable SERS signals with exposure to silver or gold metal surfaces without the use of additional protective coatings of nanomaterials. Here, novel rhodamine “dimers” and “trimers” have been created that demonstrate a higher avidity for metal nanoparticles and induce aggregation to create plasmonic “hotspots” as indicated by enhanced Raman scattering in situ. These aggregates can be formed in a colloid, on surfaces, or membrane substrates such as poly(vinylidene fluoride) for applications in biosciences. The integrity of the materials and Raman signals are maintained for months of time on different substrates. These dye materials should provide avenues for simplified in situ generation of sensors for Raman-based assays especially in settings requiring highly robust performance. American Chemical Society 2019-01-03 /pmc/articles/PMC6356857/ /pubmed/30729221 http://dx.doi.org/10.1021/acsomega.8b02970 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Bartolowits, Matthew D.
Xin, Meiguo
Petrov, Dino P.
Tague, Thomas J.
Davisson, Vincent Jo
Multimeric Rhodamine Dye-Induced Aggregation of Silver Nanoparticles for Surface-Enhanced Raman Scattering
title Multimeric Rhodamine Dye-Induced Aggregation of Silver Nanoparticles for Surface-Enhanced Raman Scattering
title_full Multimeric Rhodamine Dye-Induced Aggregation of Silver Nanoparticles for Surface-Enhanced Raman Scattering
title_fullStr Multimeric Rhodamine Dye-Induced Aggregation of Silver Nanoparticles for Surface-Enhanced Raman Scattering
title_full_unstemmed Multimeric Rhodamine Dye-Induced Aggregation of Silver Nanoparticles for Surface-Enhanced Raman Scattering
title_short Multimeric Rhodamine Dye-Induced Aggregation of Silver Nanoparticles for Surface-Enhanced Raman Scattering
title_sort multimeric rhodamine dye-induced aggregation of silver nanoparticles for surface-enhanced raman scattering
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356857/
https://www.ncbi.nlm.nih.gov/pubmed/30729221
http://dx.doi.org/10.1021/acsomega.8b02970
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