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A ‘Furry-Tale’ of Zika Virus Infection: What Have We Learned from Animal Models?

The worldwide attention that the Zika virus (ZIKV) attracted, following its declaration as a Public Health Emergency of International concern by WHO in 2016, has led to a large collective effort by the international scientific community to understand its biology. Despite the mild symptoms caused by...

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Detalles Bibliográficos
Autores principales: Nazerai, Loulieta, Pravsgaard Christensen, Jan, Randrup Thomsen, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356866/
https://www.ncbi.nlm.nih.gov/pubmed/30621317
http://dx.doi.org/10.3390/v11010029
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author Nazerai, Loulieta
Pravsgaard Christensen, Jan
Randrup Thomsen, Allan
author_facet Nazerai, Loulieta
Pravsgaard Christensen, Jan
Randrup Thomsen, Allan
author_sort Nazerai, Loulieta
collection PubMed
description The worldwide attention that the Zika virus (ZIKV) attracted, following its declaration as a Public Health Emergency of International concern by WHO in 2016, has led to a large collective effort by the international scientific community to understand its biology. Despite the mild symptoms caused by ZIKV in most infected people, the virus displays a number of worrying features, such as its ability to cause transplacental infection, fetal abnormalities and vector independent transmission through body fluids. In addition, the virus has been associated with the induction of Guillain-Barre syndrome in a number of infected individuals. With travelling, the virus has spread outside the original ZIKV endemic areas making it imperative to find ways to control it. Thus far, the large number of animal models developed to study ZIKV pathogenesis have proven to be valuable tools in understanding how the virus replicates and manifests itself in the host, its tissue tropism and the type of immune responses it induces. Still, vital questions, such as the molecular mechanisms of ZIKV persistence and the long-term consequences of ZIKV infection in the developing brain, remain unanswered. Here, we reviewed and discussed the major and most recent findings coming from animal studies and their implications for a ZIKV vaccine design.
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spelling pubmed-63568662019-02-05 A ‘Furry-Tale’ of Zika Virus Infection: What Have We Learned from Animal Models? Nazerai, Loulieta Pravsgaard Christensen, Jan Randrup Thomsen, Allan Viruses Review The worldwide attention that the Zika virus (ZIKV) attracted, following its declaration as a Public Health Emergency of International concern by WHO in 2016, has led to a large collective effort by the international scientific community to understand its biology. Despite the mild symptoms caused by ZIKV in most infected people, the virus displays a number of worrying features, such as its ability to cause transplacental infection, fetal abnormalities and vector independent transmission through body fluids. In addition, the virus has been associated with the induction of Guillain-Barre syndrome in a number of infected individuals. With travelling, the virus has spread outside the original ZIKV endemic areas making it imperative to find ways to control it. Thus far, the large number of animal models developed to study ZIKV pathogenesis have proven to be valuable tools in understanding how the virus replicates and manifests itself in the host, its tissue tropism and the type of immune responses it induces. Still, vital questions, such as the molecular mechanisms of ZIKV persistence and the long-term consequences of ZIKV infection in the developing brain, remain unanswered. Here, we reviewed and discussed the major and most recent findings coming from animal studies and their implications for a ZIKV vaccine design. MDPI 2019-01-06 /pmc/articles/PMC6356866/ /pubmed/30621317 http://dx.doi.org/10.3390/v11010029 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nazerai, Loulieta
Pravsgaard Christensen, Jan
Randrup Thomsen, Allan
A ‘Furry-Tale’ of Zika Virus Infection: What Have We Learned from Animal Models?
title A ‘Furry-Tale’ of Zika Virus Infection: What Have We Learned from Animal Models?
title_full A ‘Furry-Tale’ of Zika Virus Infection: What Have We Learned from Animal Models?
title_fullStr A ‘Furry-Tale’ of Zika Virus Infection: What Have We Learned from Animal Models?
title_full_unstemmed A ‘Furry-Tale’ of Zika Virus Infection: What Have We Learned from Animal Models?
title_short A ‘Furry-Tale’ of Zika Virus Infection: What Have We Learned from Animal Models?
title_sort ‘furry-tale’ of zika virus infection: what have we learned from animal models?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356866/
https://www.ncbi.nlm.nih.gov/pubmed/30621317
http://dx.doi.org/10.3390/v11010029
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