The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System

Autophagy and the ubiquitin proteasome system (UPS) are the two major cellular degradation pathways, which are critical for the maintenance of cell homeostasis. The two pathways differ in their mechanisms and clients. The evolutionary conserved ATG16 plays a key role in autophagy and appears to link...

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Detalles Bibliográficos
Autores principales: Xiong, Qiuhong, Li, Wenjing, Li, Ping, Yang, Min, Wu, Changxin, Eichinger, Ludwig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356889/
https://www.ncbi.nlm.nih.gov/pubmed/30577509
http://dx.doi.org/10.3390/cells8010002
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author Xiong, Qiuhong
Li, Wenjing
Li, Ping
Yang, Min
Wu, Changxin
Eichinger, Ludwig
author_facet Xiong, Qiuhong
Li, Wenjing
Li, Ping
Yang, Min
Wu, Changxin
Eichinger, Ludwig
author_sort Xiong, Qiuhong
collection PubMed
description Autophagy and the ubiquitin proteasome system (UPS) are the two major cellular degradation pathways, which are critical for the maintenance of cell homeostasis. The two pathways differ in their mechanisms and clients. The evolutionary conserved ATG16 plays a key role in autophagy and appears to link autophagy with the UPS. Here, we review the role of ATG16 in different species. We summarize the current knowledge of its functions in autophagosome membrane expansion and autophagosome formation, in Crohn’s disease, and in bacterial sequestration. In addition, we provide information on its autophagy-independent functions and its role in the crosstalk between autophagy and the UPS.
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spelling pubmed-63568892019-02-06 The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System Xiong, Qiuhong Li, Wenjing Li, Ping Yang, Min Wu, Changxin Eichinger, Ludwig Cells Review Autophagy and the ubiquitin proteasome system (UPS) are the two major cellular degradation pathways, which are critical for the maintenance of cell homeostasis. The two pathways differ in their mechanisms and clients. The evolutionary conserved ATG16 plays a key role in autophagy and appears to link autophagy with the UPS. Here, we review the role of ATG16 in different species. We summarize the current knowledge of its functions in autophagosome membrane expansion and autophagosome formation, in Crohn’s disease, and in bacterial sequestration. In addition, we provide information on its autophagy-independent functions and its role in the crosstalk between autophagy and the UPS. MDPI 2018-12-20 /pmc/articles/PMC6356889/ /pubmed/30577509 http://dx.doi.org/10.3390/cells8010002 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xiong, Qiuhong
Li, Wenjing
Li, Ping
Yang, Min
Wu, Changxin
Eichinger, Ludwig
The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System
title The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System
title_full The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System
title_fullStr The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System
title_full_unstemmed The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System
title_short The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System
title_sort role of atg16 in autophagy and the ubiquitin proteasome system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356889/
https://www.ncbi.nlm.nih.gov/pubmed/30577509
http://dx.doi.org/10.3390/cells8010002
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