Cargando…

Cancer Immunotherapy: Silencing Intracellular Negative Immune Regulators of Dendritic Cells

Dendritic cells (DCs) are capable of activating adaptive immune responses, or inducing immune suppression or tolerance. In the tumor microenvironment, the function of DCs is polarized into immune suppression that attenuates the effect of T cells, promoting differentiation of regulatory T cells and s...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yao-Hua, Yeh, I-Jeng, Lai, Ming-Derg, Liu, Kuan-Ting, Kuo, Po-Lin, Yen, Meng-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357062/
https://www.ncbi.nlm.nih.gov/pubmed/30658461
http://dx.doi.org/10.3390/cancers11010108
_version_ 1783391707817050112
author Liu, Yao-Hua
Yeh, I-Jeng
Lai, Ming-Derg
Liu, Kuan-Ting
Kuo, Po-Lin
Yen, Meng-Chi
author_facet Liu, Yao-Hua
Yeh, I-Jeng
Lai, Ming-Derg
Liu, Kuan-Ting
Kuo, Po-Lin
Yen, Meng-Chi
author_sort Liu, Yao-Hua
collection PubMed
description Dendritic cells (DCs) are capable of activating adaptive immune responses, or inducing immune suppression or tolerance. In the tumor microenvironment, the function of DCs is polarized into immune suppression that attenuates the effect of T cells, promoting differentiation of regulatory T cells and supporting tumor progression. Therefore, blocking negative immune regulators in DCs is considered a strategy of cancer immunotherapy. Antibodies can target molecules on the cell surface, but not intracellular molecules of DCs. The delivery of short-hairpin RNAs (shRNA) and small-interfering RNAs (siRNA) should be a strategy to silence specific intracellular targets in DCs. This review provides an overview of the known negative immune regulators of DCs. Moreover, a combination of shRNA/siRNA and DC vaccines, DNA vaccines in animal models, and clinical trials are also discussed.
format Online
Article
Text
id pubmed-6357062
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63570622019-02-05 Cancer Immunotherapy: Silencing Intracellular Negative Immune Regulators of Dendritic Cells Liu, Yao-Hua Yeh, I-Jeng Lai, Ming-Derg Liu, Kuan-Ting Kuo, Po-Lin Yen, Meng-Chi Cancers (Basel) Review Dendritic cells (DCs) are capable of activating adaptive immune responses, or inducing immune suppression or tolerance. In the tumor microenvironment, the function of DCs is polarized into immune suppression that attenuates the effect of T cells, promoting differentiation of regulatory T cells and supporting tumor progression. Therefore, blocking negative immune regulators in DCs is considered a strategy of cancer immunotherapy. Antibodies can target molecules on the cell surface, but not intracellular molecules of DCs. The delivery of short-hairpin RNAs (shRNA) and small-interfering RNAs (siRNA) should be a strategy to silence specific intracellular targets in DCs. This review provides an overview of the known negative immune regulators of DCs. Moreover, a combination of shRNA/siRNA and DC vaccines, DNA vaccines in animal models, and clinical trials are also discussed. MDPI 2019-01-17 /pmc/articles/PMC6357062/ /pubmed/30658461 http://dx.doi.org/10.3390/cancers11010108 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Yao-Hua
Yeh, I-Jeng
Lai, Ming-Derg
Liu, Kuan-Ting
Kuo, Po-Lin
Yen, Meng-Chi
Cancer Immunotherapy: Silencing Intracellular Negative Immune Regulators of Dendritic Cells
title Cancer Immunotherapy: Silencing Intracellular Negative Immune Regulators of Dendritic Cells
title_full Cancer Immunotherapy: Silencing Intracellular Negative Immune Regulators of Dendritic Cells
title_fullStr Cancer Immunotherapy: Silencing Intracellular Negative Immune Regulators of Dendritic Cells
title_full_unstemmed Cancer Immunotherapy: Silencing Intracellular Negative Immune Regulators of Dendritic Cells
title_short Cancer Immunotherapy: Silencing Intracellular Negative Immune Regulators of Dendritic Cells
title_sort cancer immunotherapy: silencing intracellular negative immune regulators of dendritic cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357062/
https://www.ncbi.nlm.nih.gov/pubmed/30658461
http://dx.doi.org/10.3390/cancers11010108
work_keys_str_mv AT liuyaohua cancerimmunotherapysilencingintracellularnegativeimmuneregulatorsofdendriticcells
AT yehijeng cancerimmunotherapysilencingintracellularnegativeimmuneregulatorsofdendriticcells
AT laimingderg cancerimmunotherapysilencingintracellularnegativeimmuneregulatorsofdendriticcells
AT liukuanting cancerimmunotherapysilencingintracellularnegativeimmuneregulatorsofdendriticcells
AT kuopolin cancerimmunotherapysilencingintracellularnegativeimmuneregulatorsofdendriticcells
AT yenmengchi cancerimmunotherapysilencingintracellularnegativeimmuneregulatorsofdendriticcells