Overcoming Intrinsic and Acquired Cetuximab Resistance in RAS Wild-Type Colorectal Cancer: An In Vitro Study on the Expression of HER Receptors and the Potential of Afatinib

The epidermal growth factor receptor (EGFR) is an important therapeutic target in colorectal cancer (CRC). After the initial promising results of EGFR-targeted therapies such as cetuximab, therapeutic resistance poses a challenging problem and limits the success of effective anti-EGFR cancer therapi...

Descripción completa

Detalles Bibliográficos
Autores principales: De Pauw, Ines, Lardon, Filip, Van den Bossche, Jolien, Baysal, Hasan, Pauwels, Patrick, Peeters, Marc, Vermorken, Jan Baptist, Wouters, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357064/
https://www.ncbi.nlm.nih.gov/pubmed/30650638
http://dx.doi.org/10.3390/cancers11010098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357064/
https://www.ncbi.nlm.nih.gov/pubmed/30650638
http://dx.doi.org/10.3390/cancers11010098

Ejemplares similares