Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain

Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus that was first reported in 2012. The MERS-CoV genome encodes four major structural proteins, among which the spike (S) protein has a key role in viral infection and pathogenesis. The receptor-binding domain (RBD) o...

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Detalles Bibliográficos
Autores principales: Zhou, Yusen, Yang, Yang, Huang, Jingwei, Jiang, Shibo, Du, Lanying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357101/
https://www.ncbi.nlm.nih.gov/pubmed/30646569
http://dx.doi.org/10.3390/v11010060
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author Zhou, Yusen
Yang, Yang
Huang, Jingwei
Jiang, Shibo
Du, Lanying
author_facet Zhou, Yusen
Yang, Yang
Huang, Jingwei
Jiang, Shibo
Du, Lanying
author_sort Zhou, Yusen
collection PubMed
description Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus that was first reported in 2012. The MERS-CoV genome encodes four major structural proteins, among which the spike (S) protein has a key role in viral infection and pathogenesis. The receptor-binding domain (RBD) of the S protein contains a critical neutralizing domain and is an important target for development of MERS vaccines and therapeutics. In this review, we describe the relevant features of the MERS-CoV S-protein RBD, summarize recent advances in the development of MERS-CoV RBD-based vaccines and therapeutic antibodies, and illustrate potential challenges and strategies to further improve their efficacy.
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spelling pubmed-63571012019-02-05 Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain Zhou, Yusen Yang, Yang Huang, Jingwei Jiang, Shibo Du, Lanying Viruses Review Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus that was first reported in 2012. The MERS-CoV genome encodes four major structural proteins, among which the spike (S) protein has a key role in viral infection and pathogenesis. The receptor-binding domain (RBD) of the S protein contains a critical neutralizing domain and is an important target for development of MERS vaccines and therapeutics. In this review, we describe the relevant features of the MERS-CoV S-protein RBD, summarize recent advances in the development of MERS-CoV RBD-based vaccines and therapeutic antibodies, and illustrate potential challenges and strategies to further improve their efficacy. MDPI 2019-01-14 /pmc/articles/PMC6357101/ /pubmed/30646569 http://dx.doi.org/10.3390/v11010060 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhou, Yusen
Yang, Yang
Huang, Jingwei
Jiang, Shibo
Du, Lanying
Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain
title Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain
title_full Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain
title_fullStr Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain
title_full_unstemmed Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain
title_short Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain
title_sort advances in mers-cov vaccines and therapeutics based on the receptor-binding domain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357101/
https://www.ncbi.nlm.nih.gov/pubmed/30646569
http://dx.doi.org/10.3390/v11010060
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