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An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms
Biologically active plant-based compounds, commonly referred to as phytochemicals, can influence the expression and function of various receptors and transcription factors or signaling pathways that play vital roles in cellular functions and are then involved in human health and diseases. Thus, phyt...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357109/ https://www.ncbi.nlm.nih.gov/pubmed/30609801 http://dx.doi.org/10.3390/nu11010079 |
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author | Pham, Thu Ha Lecomte, Sylvain Efstathiou, Theo Ferriere, Francois Pakdel, Farzad |
author_facet | Pham, Thu Ha Lecomte, Sylvain Efstathiou, Theo Ferriere, Francois Pakdel, Farzad |
author_sort | Pham, Thu Ha |
collection | PubMed |
description | Biologically active plant-based compounds, commonly referred to as phytochemicals, can influence the expression and function of various receptors and transcription factors or signaling pathways that play vital roles in cellular functions and are then involved in human health and diseases. Thus, phytochemicals may have a great potential to prevent and treat chronic diseases. Glyceollins, a group of phytoalexins that are isolated from soybeans, have attracted attention because they exert numerous effects on human functions and diseases, notably anticancer effects. In this review, we have presented an update on the effects of glyceollins in relation to their potential beneficial roles in human health. Despite a growing number of studies suggesting that this new family of phytochemicals can be involved in critical cellular pathways, such as estrogen receptor, protein kinase, and lipid kinase signaling pathways, future investigations will be needed to better understand their molecular mechanisms and their specific significance in biomedical applications. |
format | Online Article Text |
id | pubmed-6357109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63571092019-02-04 An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms Pham, Thu Ha Lecomte, Sylvain Efstathiou, Theo Ferriere, Francois Pakdel, Farzad Nutrients Review Biologically active plant-based compounds, commonly referred to as phytochemicals, can influence the expression and function of various receptors and transcription factors or signaling pathways that play vital roles in cellular functions and are then involved in human health and diseases. Thus, phytochemicals may have a great potential to prevent and treat chronic diseases. Glyceollins, a group of phytoalexins that are isolated from soybeans, have attracted attention because they exert numerous effects on human functions and diseases, notably anticancer effects. In this review, we have presented an update on the effects of glyceollins in relation to their potential beneficial roles in human health. Despite a growing number of studies suggesting that this new family of phytochemicals can be involved in critical cellular pathways, such as estrogen receptor, protein kinase, and lipid kinase signaling pathways, future investigations will be needed to better understand their molecular mechanisms and their specific significance in biomedical applications. MDPI 2019-01-03 /pmc/articles/PMC6357109/ /pubmed/30609801 http://dx.doi.org/10.3390/nu11010079 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pham, Thu Ha Lecomte, Sylvain Efstathiou, Theo Ferriere, Francois Pakdel, Farzad An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms |
title | An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms |
title_full | An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms |
title_fullStr | An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms |
title_full_unstemmed | An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms |
title_short | An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms |
title_sort | update on the effects of glyceollins on human health: possible anticancer effects and underlying mechanisms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357109/ https://www.ncbi.nlm.nih.gov/pubmed/30609801 http://dx.doi.org/10.3390/nu11010079 |
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