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An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms

Biologically active plant-based compounds, commonly referred to as phytochemicals, can influence the expression and function of various receptors and transcription factors or signaling pathways that play vital roles in cellular functions and are then involved in human health and diseases. Thus, phyt...

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Autores principales: Pham, Thu Ha, Lecomte, Sylvain, Efstathiou, Theo, Ferriere, Francois, Pakdel, Farzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357109/
https://www.ncbi.nlm.nih.gov/pubmed/30609801
http://dx.doi.org/10.3390/nu11010079
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author Pham, Thu Ha
Lecomte, Sylvain
Efstathiou, Theo
Ferriere, Francois
Pakdel, Farzad
author_facet Pham, Thu Ha
Lecomte, Sylvain
Efstathiou, Theo
Ferriere, Francois
Pakdel, Farzad
author_sort Pham, Thu Ha
collection PubMed
description Biologically active plant-based compounds, commonly referred to as phytochemicals, can influence the expression and function of various receptors and transcription factors or signaling pathways that play vital roles in cellular functions and are then involved in human health and diseases. Thus, phytochemicals may have a great potential to prevent and treat chronic diseases. Glyceollins, a group of phytoalexins that are isolated from soybeans, have attracted attention because they exert numerous effects on human functions and diseases, notably anticancer effects. In this review, we have presented an update on the effects of glyceollins in relation to their potential beneficial roles in human health. Despite a growing number of studies suggesting that this new family of phytochemicals can be involved in critical cellular pathways, such as estrogen receptor, protein kinase, and lipid kinase signaling pathways, future investigations will be needed to better understand their molecular mechanisms and their specific significance in biomedical applications.
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spelling pubmed-63571092019-02-04 An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms Pham, Thu Ha Lecomte, Sylvain Efstathiou, Theo Ferriere, Francois Pakdel, Farzad Nutrients Review Biologically active plant-based compounds, commonly referred to as phytochemicals, can influence the expression and function of various receptors and transcription factors or signaling pathways that play vital roles in cellular functions and are then involved in human health and diseases. Thus, phytochemicals may have a great potential to prevent and treat chronic diseases. Glyceollins, a group of phytoalexins that are isolated from soybeans, have attracted attention because they exert numerous effects on human functions and diseases, notably anticancer effects. In this review, we have presented an update on the effects of glyceollins in relation to their potential beneficial roles in human health. Despite a growing number of studies suggesting that this new family of phytochemicals can be involved in critical cellular pathways, such as estrogen receptor, protein kinase, and lipid kinase signaling pathways, future investigations will be needed to better understand their molecular mechanisms and their specific significance in biomedical applications. MDPI 2019-01-03 /pmc/articles/PMC6357109/ /pubmed/30609801 http://dx.doi.org/10.3390/nu11010079 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pham, Thu Ha
Lecomte, Sylvain
Efstathiou, Theo
Ferriere, Francois
Pakdel, Farzad
An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms
title An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms
title_full An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms
title_fullStr An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms
title_full_unstemmed An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms
title_short An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms
title_sort update on the effects of glyceollins on human health: possible anticancer effects and underlying mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357109/
https://www.ncbi.nlm.nih.gov/pubmed/30609801
http://dx.doi.org/10.3390/nu11010079
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