Cargando…

Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4

The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and caused continual outbreaks worldwide with high mortality. However, no effective anti-MERS-CoV drug is currently available. Recently, numerous evolutionary studies have suggested that MERS-CoV originated from bat coronavi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Shuai, Lan, Qiaoshuai, Pu, Jing, Wang, Cong, Liu, Zezhong, Xu, Wei, Wang, Qian, Liu, Huan, Jiang, Shibo, Lu, Lu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357153/ https://www.ncbi.nlm.nih.gov/pubmed/30646495 http://dx.doi.org/10.3390/v11010056

Ejemplares similares

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
por: Xia, Shuai, et al.
Publicado: (2020)

Combining a Fusion Inhibitory Peptide Targeting the MERS-CoV S2 Protein HR1 Domain and a Neutralizing Antibody Specific for the S1 Protein Receptor-Binding Domain (RBD) Showed Potent Synergism against Pseudotyped MERS-CoV with or without Mutations in RBD
por: Wang, Cong, et al.
Publicado: (2019)

A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses
por: Cai, Yanxing, et al.
Publicado: (2021)

Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26
por: Wang, Qihui, et al.
Publicado: (2014)

The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
por: Xia, Shuai, et al.
Publicado: (2020)

Peptide-Based Membrane Fusion Inhibitors Targeting HCoV-229E Spike Protein HR1 and HR2 Domains
por: Xia, Shuai, et al.
Publicado: (2018)

A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases
por: Zhou, Jie, et al.
Publicado: (2022)

Genomic Characterization of Diverse Bat Coronavirus HKU10 in Hipposideros Bats
por: Wang, Ning, et al.
Publicado: (2021)

Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein
por: Han, Xue, et al.
Publicado: (2017)

Lipopeptide-based pan-CoV fusion inhibitors potently inhibit HIV-1 infection
por: Lan, Qiaoshuai, et al.
Publicado: (2021)

Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5
por: Woo, Patrick CY, et al.
Publicado: (2012)

Putative Receptor Binding Domain of Bat-Derived Coronavirus HKU9 Spike Protein: Evolution of Betacoronavirus Receptor Binding Motifs
por: Huang, Canping, et al.
Publicado: (2016)

Origins of HIV, HCoV-HKU1, SFTSV, and MERS-CoV and Beyond
por: Liu, Wenli, et al.
Publicado: (2022)

Inefficiency of Sera from Mice Treated with Pseudotyped SARS-CoV to Neutralize 2019-nCoV Infection
por: Liu, Zezhong, et al.
Publicado: (2020)

25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses
por: Lan, Qiaoshuai, et al.
Publicado: (2021)

SARS‐unique fold in the Rousettus bat coronavirus HKU9
por: Hammond, Robert G., et al.
Publicado: (2017)

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike
por: Xia, Shuai, et al.
Publicado: (2019)

The Analogs of Furanyl Methylidene Rhodanine Exhibit Broad-Spectrum Inhibitory and Inactivating Activities against Enveloped Viruses, including SARS-CoV-2 and Its Variants
por: Pu, Jing, et al.
Publicado: (2022)

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
por: Xia, Shuai, et al.
Publicado: (2020)

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein
por: Xia, Shuai, et al.
Publicado: (2014)

High-throughput screening of mutations affecting SARS-CoV-2 spike functions
por: Xia, Shuai, et al.
Publicado: (2023)

A New Bat-HKU2–like Coronavirus in Swine, China, 2017
por: Gong, Lang, et al.
Publicado: (2017)

Structure of the SARS-Unique Domain C From the Bat Coronavirus HKU4
por: Staup, Andrew J., et al.
Publicado: (2019)

Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
por: Zhou, Peng, et al.
Publicado: (2018)

Retraction Note to: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion
por: Wang, Xinling, et al.
Publicado: (2020)

RETRACTED ARTICLE: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion
por: Wang, Xinling, et al.
Publicado: (2020)

A Palmitic Acid-Conjugated, Peptide-Based pan-CoV Fusion Inhibitor Potently Inhibits Infection of SARS-CoV-2 Omicron and Other Variants of Concern
por: Lan, Qiaoshuai, et al.
Publicado: (2022)

Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond
por: Lu, Guangwen, et al.
Publicado: (2015)

Complete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genome
por: Lau, Susanna K.P., et al.
Publicado: (2007)

Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels
por: Zhang, Wei, et al.
Publicado: (2019)

Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1
por: Ou, Xiuyuan, et al.
Publicado: (2017)

Isolation and Characterization of Dromedary Camel Coronavirus UAE-HKU23 from Dromedaries of the Middle East: Minimal Serological Cross-Reactivity between MERS Coronavirus and Dromedary Camel Coronavirus UAE-HKU23
por: Woo, Patrick C. Y., et al.
Publicado: (2016)

A Truncated Receptor-Binding Domain of MERS-CoV Spike Protein Potently Inhibits MERS-CoV Infection and Induces Strong Neutralizing Antibody Responses: Implication for Developing Therapeutics and Vaccines
por: Du, Lanying, et al.
Publicado: (2013)

An HR2-Mimicking Sulfonyl-γ-AApeptide Is a Potent Pan-coronavirus Fusion Inhibitor with Strong Blood–Brain Barrier Permeability, Long Half-Life, and Promising Oral Bioavailability
por: Xue, Songyi, et al.
Publicado: (2023)

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells
por: Chu, Hin, et al.
Publicado: (2018)

Correction: A Truncated Receptor-Binding Domain of MERS-CoV Spike Protein Potently Inhibits MERS-CoV Infection and Induces Strong Neutralizing Antibody Responses: Implication for Developing Therapeutics and Vaccines
por: Du, Lanying, et al.
Publicado: (2022)

Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution
por: Yu, Jinfang, et al.
Publicado: (2020)

Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)
por: St. John, Sarah E., et al.
Publicado: (2015)

A Fusion Peptide in the Spike Protein of MERS Coronavirus
por: Alsaadi, Entedar A. J., et al.
Publicado: (2019)

Deciphering the O-Glycosylation of HKU1 Spike Protein With the Dual-Functional Hydrophilic Interaction Chromatography Materials
por: Cui, Yun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1tkruqdi27udtb0j78j1sh6dde