Cargando…
Autophagy in Chronic Kidney Diseases
Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis. In clinical studies, autophagy activations and inhibitions are linked to acute kidney...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357204/ https://www.ncbi.nlm.nih.gov/pubmed/30654583 http://dx.doi.org/10.3390/cells8010061 |
_version_ | 1783391749339611136 |
---|---|
author | Lin, Tien-An Wu, Victor Chien-Chia Wang, Chao-Yung |
author_facet | Lin, Tien-An Wu, Victor Chien-Chia Wang, Chao-Yung |
author_sort | Lin, Tien-An |
collection | PubMed |
description | Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis. In clinical studies, autophagy activations and inhibitions are linked to acute kidney injuries, chronic kidney diseases, diabetic nephropathies, and polycystic kidney diseases. Oxidative stress, inflammation, and mitochondrial dysfunction, which are implicated as important mechanisms underlying many kidney diseases, modulate the autophagy activation and inhibition and lead to cellular recycling dysfunction. Abnormal autophagy function can induce loss of podocytes, damage proximal tubular cells, and glomerulosclerosis. After acute kidney injuries, activated autophagy protects tubular cells from apoptosis and enhances cellular regeneration. Patients with chronic kidney diseases have impaired autophagy that cannot be reversed by hemodialysis. Multiple nephrotoxic medications also alter the autophagy signaling, by which the mechanistic insights of the drugs are revealed, thus providing the unique opportunity to manage the nephrotoxicity of these drugs. In this review, we summarize the current concepts of autophagy and its molecular aspects in different kidney cells pathophysiology. We also discuss the current evidence of autophagy in acute kidney injury, chronic kidney disease, toxic effects of drugs, and aging kidneys. In addition, we examine therapeutic possibilities targeting the autophagy system in kidney diseases. |
format | Online Article Text |
id | pubmed-6357204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63572042019-02-06 Autophagy in Chronic Kidney Diseases Lin, Tien-An Wu, Victor Chien-Chia Wang, Chao-Yung Cells Review Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis. In clinical studies, autophagy activations and inhibitions are linked to acute kidney injuries, chronic kidney diseases, diabetic nephropathies, and polycystic kidney diseases. Oxidative stress, inflammation, and mitochondrial dysfunction, which are implicated as important mechanisms underlying many kidney diseases, modulate the autophagy activation and inhibition and lead to cellular recycling dysfunction. Abnormal autophagy function can induce loss of podocytes, damage proximal tubular cells, and glomerulosclerosis. After acute kidney injuries, activated autophagy protects tubular cells from apoptosis and enhances cellular regeneration. Patients with chronic kidney diseases have impaired autophagy that cannot be reversed by hemodialysis. Multiple nephrotoxic medications also alter the autophagy signaling, by which the mechanistic insights of the drugs are revealed, thus providing the unique opportunity to manage the nephrotoxicity of these drugs. In this review, we summarize the current concepts of autophagy and its molecular aspects in different kidney cells pathophysiology. We also discuss the current evidence of autophagy in acute kidney injury, chronic kidney disease, toxic effects of drugs, and aging kidneys. In addition, we examine therapeutic possibilities targeting the autophagy system in kidney diseases. MDPI 2019-01-16 /pmc/articles/PMC6357204/ /pubmed/30654583 http://dx.doi.org/10.3390/cells8010061 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lin, Tien-An Wu, Victor Chien-Chia Wang, Chao-Yung Autophagy in Chronic Kidney Diseases |
title | Autophagy in Chronic Kidney Diseases |
title_full | Autophagy in Chronic Kidney Diseases |
title_fullStr | Autophagy in Chronic Kidney Diseases |
title_full_unstemmed | Autophagy in Chronic Kidney Diseases |
title_short | Autophagy in Chronic Kidney Diseases |
title_sort | autophagy in chronic kidney diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357204/ https://www.ncbi.nlm.nih.gov/pubmed/30654583 http://dx.doi.org/10.3390/cells8010061 |
work_keys_str_mv | AT lintienan autophagyinchronickidneydiseases AT wuvictorchienchia autophagyinchronickidneydiseases AT wangchaoyung autophagyinchronickidneydiseases |