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In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)

The potential bioactivities for alleviating Metabolic Syndrome associated risk factors were evaluated in carob (Ceratonia siliqua L.) fruit by-products, i.e. seed peel, germ and pod. Carob germ and seed peel showed higher phenolic content than pod (99.72, 80.24 and 47.06 μmol GAE g(−1), respectively...

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Autores principales: Rico, D., Martín-Diana, A.B., Martínez-Villaluenga, C., Aguirre, L., Silván, J.M., Dueñas, M., De Luis, D.A., Lasa, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357213/
https://www.ncbi.nlm.nih.gov/pubmed/30775572
http://dx.doi.org/10.1016/j.heliyon.2019.e01175
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author Rico, D.
Martín-Diana, A.B.
Martínez-Villaluenga, C.
Aguirre, L.
Silván, J.M.
Dueñas, M.
De Luis, D.A.
Lasa, A.
author_facet Rico, D.
Martín-Diana, A.B.
Martínez-Villaluenga, C.
Aguirre, L.
Silván, J.M.
Dueñas, M.
De Luis, D.A.
Lasa, A.
author_sort Rico, D.
collection PubMed
description The potential bioactivities for alleviating Metabolic Syndrome associated risk factors were evaluated in carob (Ceratonia siliqua L.) fruit by-products, i.e. seed peel, germ and pod. Carob germ and seed peel showed higher phenolic content than pod (99.72, 80.24 and 47.06 μmol GAE g(−1), respectively). Pod mostly contained gallic acid and gallotannins; seed peel and germ's showed as most abundant polyphenols quercetin and apigenin derivatives. Carob pod and seed peel revealed stronger antioxidant capacities compared to germ. The strongest antihypertensive activity was found in seed peel, followed by pod and germ. Anti-inflammatory activity showed inhibition of NO production in LPS-induced macrophages, although only pod was able of reducing pro-inflammatory mediators (TNF-α andPGD(2)). Finally, fat accumulation on mature adipocytes was reduced by carob seed peel and pod extracts. This work shows the potential use of pod carob by-products as food ingredients with special relevance of carob pod for attenuating metabolic syndrome.
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spelling pubmed-63572132019-02-15 In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS) Rico, D. Martín-Diana, A.B. Martínez-Villaluenga, C. Aguirre, L. Silván, J.M. Dueñas, M. De Luis, D.A. Lasa, A. Heliyon Article The potential bioactivities for alleviating Metabolic Syndrome associated risk factors were evaluated in carob (Ceratonia siliqua L.) fruit by-products, i.e. seed peel, germ and pod. Carob germ and seed peel showed higher phenolic content than pod (99.72, 80.24 and 47.06 μmol GAE g(−1), respectively). Pod mostly contained gallic acid and gallotannins; seed peel and germ's showed as most abundant polyphenols quercetin and apigenin derivatives. Carob pod and seed peel revealed stronger antioxidant capacities compared to germ. The strongest antihypertensive activity was found in seed peel, followed by pod and germ. Anti-inflammatory activity showed inhibition of NO production in LPS-induced macrophages, although only pod was able of reducing pro-inflammatory mediators (TNF-α andPGD(2)). Finally, fat accumulation on mature adipocytes was reduced by carob seed peel and pod extracts. This work shows the potential use of pod carob by-products as food ingredients with special relevance of carob pod for attenuating metabolic syndrome. Elsevier 2019-01-30 /pmc/articles/PMC6357213/ /pubmed/30775572 http://dx.doi.org/10.1016/j.heliyon.2019.e01175 Text en © 2019 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Rico, D.
Martín-Diana, A.B.
Martínez-Villaluenga, C.
Aguirre, L.
Silván, J.M.
Dueñas, M.
De Luis, D.A.
Lasa, A.
In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)
title In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)
title_full In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)
title_fullStr In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)
title_full_unstemmed In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)
title_short In vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (MetS)
title_sort in vitro approach for evaluation of carob by-products as source bioactive ingredients with potential to attenuate metabolic syndrome (mets)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357213/
https://www.ncbi.nlm.nih.gov/pubmed/30775572
http://dx.doi.org/10.1016/j.heliyon.2019.e01175
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