Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches

Use of chimeric antigen receptors (CARs) as the basis of targeted adoptive T cell therapies has enabled dramatic efficacy against multiple hematopoietic malignancies, but potency against bulky and solid tumors has lagged, potentially due to insufficient CAR-T cell expansion and persistence. To impro...

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Detalles Bibliográficos
Autores principales: Duong, MyLinh T., Collinson-Pautz, Matthew R., Morschl, Eva, Lu, An, Szymanski, Slawomir P., Zhang, Ming, Brandt, Mary E., Chang, Wei-Chun, Sharp, Kelly L., Toler, Steven M., Slawin, Kevin M., Foster, Aaron E., Spencer, David M., Bayle, J. Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357218/
https://www.ncbi.nlm.nih.gov/pubmed/30740516
http://dx.doi.org/10.1016/j.omto.2018.12.009

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