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Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases

Cardiovascular diseases are life-threatening illnesses with high morbidity and mortality. Suppressed vagal (parasympathetic) activity and increased sympathetic activity are involved in these diseases. Currently, pharmacological interventions primarily aim to inhibit over-excitation of sympathetic ne...

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Detalles Bibliográficos
Autores principales: Liu, Longzhu, Zhao, Ming, Yu, Xiaojiang, Zang, Weijin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357265/
https://www.ncbi.nlm.nih.gov/pubmed/30218283
http://dx.doi.org/10.1007/s12264-018-0286-7
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author Liu, Longzhu
Zhao, Ming
Yu, Xiaojiang
Zang, Weijin
author_facet Liu, Longzhu
Zhao, Ming
Yu, Xiaojiang
Zang, Weijin
author_sort Liu, Longzhu
collection PubMed
description Cardiovascular diseases are life-threatening illnesses with high morbidity and mortality. Suppressed vagal (parasympathetic) activity and increased sympathetic activity are involved in these diseases. Currently, pharmacological interventions primarily aim to inhibit over-excitation of sympathetic nerves, while vagal modulation has been largely neglected. Many studies have demonstrated that increased vagal activity reduces cardiovascular risk factors in both animal models and human patients. Therefore, the improvement of vagal activity may be an alternate approach for the treatment of cardiovascular diseases. However, drugs used for vagus nerve activation in cardiovascular diseases are limited in the clinic. In this review, we provide an overview of the potential drug targets for modulating vagal nerve activation, including muscarinic, and β-adrenergic receptors. In addition, vagomimetic drugs (such as choline, acetylcholine, and pyridostigmine) and the mechanism underlying their cardiovascular protective effects are also discussed.
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spelling pubmed-63572652019-02-24 Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases Liu, Longzhu Zhao, Ming Yu, Xiaojiang Zang, Weijin Neurosci Bull Review Cardiovascular diseases are life-threatening illnesses with high morbidity and mortality. Suppressed vagal (parasympathetic) activity and increased sympathetic activity are involved in these diseases. Currently, pharmacological interventions primarily aim to inhibit over-excitation of sympathetic nerves, while vagal modulation has been largely neglected. Many studies have demonstrated that increased vagal activity reduces cardiovascular risk factors in both animal models and human patients. Therefore, the improvement of vagal activity may be an alternate approach for the treatment of cardiovascular diseases. However, drugs used for vagus nerve activation in cardiovascular diseases are limited in the clinic. In this review, we provide an overview of the potential drug targets for modulating vagal nerve activation, including muscarinic, and β-adrenergic receptors. In addition, vagomimetic drugs (such as choline, acetylcholine, and pyridostigmine) and the mechanism underlying their cardiovascular protective effects are also discussed. Springer Singapore 2018-09-14 /pmc/articles/PMC6357265/ /pubmed/30218283 http://dx.doi.org/10.1007/s12264-018-0286-7 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Liu, Longzhu
Zhao, Ming
Yu, Xiaojiang
Zang, Weijin
Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases
title Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases
title_full Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases
title_fullStr Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases
title_full_unstemmed Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases
title_short Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases
title_sort pharmacological modulation of vagal nerve activity in cardiovascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357265/
https://www.ncbi.nlm.nih.gov/pubmed/30218283
http://dx.doi.org/10.1007/s12264-018-0286-7
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