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Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases
Cardiovascular diseases are life-threatening illnesses with high morbidity and mortality. Suppressed vagal (parasympathetic) activity and increased sympathetic activity are involved in these diseases. Currently, pharmacological interventions primarily aim to inhibit over-excitation of sympathetic ne...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357265/ https://www.ncbi.nlm.nih.gov/pubmed/30218283 http://dx.doi.org/10.1007/s12264-018-0286-7 |
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author | Liu, Longzhu Zhao, Ming Yu, Xiaojiang Zang, Weijin |
author_facet | Liu, Longzhu Zhao, Ming Yu, Xiaojiang Zang, Weijin |
author_sort | Liu, Longzhu |
collection | PubMed |
description | Cardiovascular diseases are life-threatening illnesses with high morbidity and mortality. Suppressed vagal (parasympathetic) activity and increased sympathetic activity are involved in these diseases. Currently, pharmacological interventions primarily aim to inhibit over-excitation of sympathetic nerves, while vagal modulation has been largely neglected. Many studies have demonstrated that increased vagal activity reduces cardiovascular risk factors in both animal models and human patients. Therefore, the improvement of vagal activity may be an alternate approach for the treatment of cardiovascular diseases. However, drugs used for vagus nerve activation in cardiovascular diseases are limited in the clinic. In this review, we provide an overview of the potential drug targets for modulating vagal nerve activation, including muscarinic, and β-adrenergic receptors. In addition, vagomimetic drugs (such as choline, acetylcholine, and pyridostigmine) and the mechanism underlying their cardiovascular protective effects are also discussed. |
format | Online Article Text |
id | pubmed-6357265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-63572652019-02-24 Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases Liu, Longzhu Zhao, Ming Yu, Xiaojiang Zang, Weijin Neurosci Bull Review Cardiovascular diseases are life-threatening illnesses with high morbidity and mortality. Suppressed vagal (parasympathetic) activity and increased sympathetic activity are involved in these diseases. Currently, pharmacological interventions primarily aim to inhibit over-excitation of sympathetic nerves, while vagal modulation has been largely neglected. Many studies have demonstrated that increased vagal activity reduces cardiovascular risk factors in both animal models and human patients. Therefore, the improvement of vagal activity may be an alternate approach for the treatment of cardiovascular diseases. However, drugs used for vagus nerve activation in cardiovascular diseases are limited in the clinic. In this review, we provide an overview of the potential drug targets for modulating vagal nerve activation, including muscarinic, and β-adrenergic receptors. In addition, vagomimetic drugs (such as choline, acetylcholine, and pyridostigmine) and the mechanism underlying their cardiovascular protective effects are also discussed. Springer Singapore 2018-09-14 /pmc/articles/PMC6357265/ /pubmed/30218283 http://dx.doi.org/10.1007/s12264-018-0286-7 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Liu, Longzhu Zhao, Ming Yu, Xiaojiang Zang, Weijin Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases |
title | Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases |
title_full | Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases |
title_fullStr | Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases |
title_full_unstemmed | Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases |
title_short | Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases |
title_sort | pharmacological modulation of vagal nerve activity in cardiovascular diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357265/ https://www.ncbi.nlm.nih.gov/pubmed/30218283 http://dx.doi.org/10.1007/s12264-018-0286-7 |
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