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Lymph Node Lymphatic Endothelial Cell Expansion and Contraction and the Programming of the Immune Response
Lymphatic endothelial cells (LECs) form the structure of the lymphatic vessels and the sinuses of the lymph nodes, positioning them to be key players in many different aspects of the immune response. Following an inflammatory stimulus, LECs produce chemokines that recruit immune cells to the lymph n...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357284/ https://www.ncbi.nlm.nih.gov/pubmed/30740101 http://dx.doi.org/10.3389/fimmu.2019.00036 |
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author | Lucas, Erin D. Tamburini, Beth A. J. |
author_facet | Lucas, Erin D. Tamburini, Beth A. J. |
author_sort | Lucas, Erin D. |
collection | PubMed |
description | Lymphatic endothelial cells (LECs) form the structure of the lymphatic vessels and the sinuses of the lymph nodes, positioning them to be key players in many different aspects of the immune response. Following an inflammatory stimulus, LECs produce chemokines that recruit immune cells to the lymph nodes. The recruitment of immune cells aids in the coordination of both LEC and lymph node expansion and contraction. More recent data has demonstrated that to coordinate LEC division and death, cell surface molecules, such as PD-L1 and interferon receptors, are required. During homeostasis, LECs use PD-L1 to maintain peripheral tolerance by presenting specific peripheral tissue antigens in order to eliminate tissue specific responses. LECs also have the capacity to acquire, present, and exchange foreign antigens following viral infection or immunization. Here we will review how lymph node LECs require immune cells to expand and contract in response to an immune stimulus, the factors involved and how direct LEC-immune cell interactions are important for programming immunity. |
format | Online Article Text |
id | pubmed-6357284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63572842019-02-08 Lymph Node Lymphatic Endothelial Cell Expansion and Contraction and the Programming of the Immune Response Lucas, Erin D. Tamburini, Beth A. J. Front Immunol Immunology Lymphatic endothelial cells (LECs) form the structure of the lymphatic vessels and the sinuses of the lymph nodes, positioning them to be key players in many different aspects of the immune response. Following an inflammatory stimulus, LECs produce chemokines that recruit immune cells to the lymph nodes. The recruitment of immune cells aids in the coordination of both LEC and lymph node expansion and contraction. More recent data has demonstrated that to coordinate LEC division and death, cell surface molecules, such as PD-L1 and interferon receptors, are required. During homeostasis, LECs use PD-L1 to maintain peripheral tolerance by presenting specific peripheral tissue antigens in order to eliminate tissue specific responses. LECs also have the capacity to acquire, present, and exchange foreign antigens following viral infection or immunization. Here we will review how lymph node LECs require immune cells to expand and contract in response to an immune stimulus, the factors involved and how direct LEC-immune cell interactions are important for programming immunity. Frontiers Media S.A. 2019-01-25 /pmc/articles/PMC6357284/ /pubmed/30740101 http://dx.doi.org/10.3389/fimmu.2019.00036 Text en Copyright © 2019 Lucas and Tamburini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lucas, Erin D. Tamburini, Beth A. J. Lymph Node Lymphatic Endothelial Cell Expansion and Contraction and the Programming of the Immune Response |
title | Lymph Node Lymphatic Endothelial Cell Expansion and Contraction and the Programming of the Immune Response |
title_full | Lymph Node Lymphatic Endothelial Cell Expansion and Contraction and the Programming of the Immune Response |
title_fullStr | Lymph Node Lymphatic Endothelial Cell Expansion and Contraction and the Programming of the Immune Response |
title_full_unstemmed | Lymph Node Lymphatic Endothelial Cell Expansion and Contraction and the Programming of the Immune Response |
title_short | Lymph Node Lymphatic Endothelial Cell Expansion and Contraction and the Programming of the Immune Response |
title_sort | lymph node lymphatic endothelial cell expansion and contraction and the programming of the immune response |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357284/ https://www.ncbi.nlm.nih.gov/pubmed/30740101 http://dx.doi.org/10.3389/fimmu.2019.00036 |
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