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A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study

BACKGROUND: Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. RESULTS: In our study, associations between 4956 GWAS catalog reported S...

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Autores principales: Zhao, Xueyan, Geng, Xin, Srinivasasainagendra, Vinodh, Chaudhary, Ninad, Judd, Suzanne, Wadley, Virginia, Gutiérrez, Orlando M., Wang, Henry, Lange, Ethan M., Lange, Leslie A., Woo, Daniel, Unverzagt, Frederick W., Safford, Monika, Cushman, Mary, Limdi, Nita, Quarells, Rakale, Arnett, Donna K., Irvin, Marguerite R., Zhi, Degui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357353/
https://www.ncbi.nlm.nih.gov/pubmed/30704471
http://dx.doi.org/10.1186/s12920-018-0462-7
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author Zhao, Xueyan
Geng, Xin
Srinivasasainagendra, Vinodh
Chaudhary, Ninad
Judd, Suzanne
Wadley, Virginia
Gutiérrez, Orlando M.
Wang, Henry
Lange, Ethan M.
Lange, Leslie A.
Woo, Daniel
Unverzagt, Frederick W.
Safford, Monika
Cushman, Mary
Limdi, Nita
Quarells, Rakale
Arnett, Donna K.
Irvin, Marguerite R.
Zhi, Degui
author_facet Zhao, Xueyan
Geng, Xin
Srinivasasainagendra, Vinodh
Chaudhary, Ninad
Judd, Suzanne
Wadley, Virginia
Gutiérrez, Orlando M.
Wang, Henry
Lange, Ethan M.
Lange, Leslie A.
Woo, Daniel
Unverzagt, Frederick W.
Safford, Monika
Cushman, Mary
Limdi, Nita
Quarells, Rakale
Arnett, Donna K.
Irvin, Marguerite R.
Zhi, Degui
author_sort Zhao, Xueyan
collection PubMed
description BACKGROUND: Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. RESULTS: In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. CONCLUSION: Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12920-018-0462-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-63573532019-02-07 A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study Zhao, Xueyan Geng, Xin Srinivasasainagendra, Vinodh Chaudhary, Ninad Judd, Suzanne Wadley, Virginia Gutiérrez, Orlando M. Wang, Henry Lange, Ethan M. Lange, Leslie A. Woo, Daniel Unverzagt, Frederick W. Safford, Monika Cushman, Mary Limdi, Nita Quarells, Rakale Arnett, Donna K. Irvin, Marguerite R. Zhi, Degui BMC Med Genomics Research BACKGROUND: Cardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited. RESULTS: In our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans. CONCLUSION: Our cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12920-018-0462-7) contains supplementary material, which is available to authorized users. BioMed Central 2019-01-31 /pmc/articles/PMC6357353/ /pubmed/30704471 http://dx.doi.org/10.1186/s12920-018-0462-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zhao, Xueyan
Geng, Xin
Srinivasasainagendra, Vinodh
Chaudhary, Ninad
Judd, Suzanne
Wadley, Virginia
Gutiérrez, Orlando M.
Wang, Henry
Lange, Ethan M.
Lange, Leslie A.
Woo, Daniel
Unverzagt, Frederick W.
Safford, Monika
Cushman, Mary
Limdi, Nita
Quarells, Rakale
Arnett, Donna K.
Irvin, Marguerite R.
Zhi, Degui
A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
title A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
title_full A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
title_fullStr A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
title_full_unstemmed A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
title_short A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study
title_sort phewas study of a large observational epidemiological cohort of african americans from the regards study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357353/
https://www.ncbi.nlm.nih.gov/pubmed/30704471
http://dx.doi.org/10.1186/s12920-018-0462-7
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