Cargando…

Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults

BACKGROUND: Regular loading of tendons may counteract the negative effects of aging. However, the influence of strength training loading magnitude on tendon mechanical properties and its relation to matrix collagen content and collagen cross-linking is sparsely described in older adults. The purpose...

Descripción completa

Detalles Bibliográficos
Autores principales: Eriksen, Christian S., Svensson, Rene B., Gylling, Anne T., Couppé, Christian, Magnusson, S. Peter, Kjaer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357404/
https://www.ncbi.nlm.nih.gov/pubmed/30704412
http://dx.doi.org/10.1186/s12877-019-1043-0
_version_ 1783391783649017856
author Eriksen, Christian S.
Svensson, Rene B.
Gylling, Anne T.
Couppé, Christian
Magnusson, S. Peter
Kjaer, Michael
author_facet Eriksen, Christian S.
Svensson, Rene B.
Gylling, Anne T.
Couppé, Christian
Magnusson, S. Peter
Kjaer, Michael
author_sort Eriksen, Christian S.
collection PubMed
description BACKGROUND: Regular loading of tendons may counteract the negative effects of aging. However, the influence of strength training loading magnitude on tendon mechanical properties and its relation to matrix collagen content and collagen cross-linking is sparsely described in older adults. The purpose of the present study was to compare the effects of moderate or high load resistance training on tendon matrix and its mechanical properties. METHODS: Seventeen women and 19 men, age 62–70 years, were recruited and randomly allocated to 12 months of heavy load resistance training (HRT), moderate load resistance training (MRT) or control (CON). Pre- and post-intervention testing comprised isometric quadriceps strength test (IsoMVC), ultrasound based testing of in vivo patellar tendon (PT) mechanical properties, MRI-based measurement of PT cross-sectional area (CSA), PT biopsies for assessment of fibril morphology, collagen content, enzymatic cross-links, and tendon fluorescence as a measure of advanced glycation end-products (AGEs). RESULTS: Thirty three participants completed the intervention and were included in the data analysis. IsoMVC increased more after HRT (+ 21%) than MRT (+ 8%) and CON (+ 7%) (p < 0.05). Tendon stiffness (p < 0.05) and Young’s modulus (p = 0.05) were also differently affected by training load with a reduction in CON and MRT but not in HRT. PT-CSA increased equally after both MRT and HRT. Collagen content, fibril morphology, enzymatic cross-links, and tendon fluorescence were unaffected by training. CONCLUSION: Despite equal improvements in tendon size after moderate and heavy load resistance training, only heavy. load training seemed to maintain tendon mechanical properties in old age. The effect of load magnitude on tendon biomechanics was unrelated to changes of major load bearing matrix components in the tendon core. The study is a sub-study of the LISA study, which was registered at http://clinicaltrials.gov (NCT02123641) April 25th 2014.
format Online
Article
Text
id pubmed-6357404
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-63574042019-02-07 Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults Eriksen, Christian S. Svensson, Rene B. Gylling, Anne T. Couppé, Christian Magnusson, S. Peter Kjaer, Michael BMC Geriatr Research Article BACKGROUND: Regular loading of tendons may counteract the negative effects of aging. However, the influence of strength training loading magnitude on tendon mechanical properties and its relation to matrix collagen content and collagen cross-linking is sparsely described in older adults. The purpose of the present study was to compare the effects of moderate or high load resistance training on tendon matrix and its mechanical properties. METHODS: Seventeen women and 19 men, age 62–70 years, were recruited and randomly allocated to 12 months of heavy load resistance training (HRT), moderate load resistance training (MRT) or control (CON). Pre- and post-intervention testing comprised isometric quadriceps strength test (IsoMVC), ultrasound based testing of in vivo patellar tendon (PT) mechanical properties, MRI-based measurement of PT cross-sectional area (CSA), PT biopsies for assessment of fibril morphology, collagen content, enzymatic cross-links, and tendon fluorescence as a measure of advanced glycation end-products (AGEs). RESULTS: Thirty three participants completed the intervention and were included in the data analysis. IsoMVC increased more after HRT (+ 21%) than MRT (+ 8%) and CON (+ 7%) (p < 0.05). Tendon stiffness (p < 0.05) and Young’s modulus (p = 0.05) were also differently affected by training load with a reduction in CON and MRT but not in HRT. PT-CSA increased equally after both MRT and HRT. Collagen content, fibril morphology, enzymatic cross-links, and tendon fluorescence were unaffected by training. CONCLUSION: Despite equal improvements in tendon size after moderate and heavy load resistance training, only heavy. load training seemed to maintain tendon mechanical properties in old age. The effect of load magnitude on tendon biomechanics was unrelated to changes of major load bearing matrix components in the tendon core. The study is a sub-study of the LISA study, which was registered at http://clinicaltrials.gov (NCT02123641) April 25th 2014. BioMed Central 2019-01-31 /pmc/articles/PMC6357404/ /pubmed/30704412 http://dx.doi.org/10.1186/s12877-019-1043-0 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Eriksen, Christian S.
Svensson, Rene B.
Gylling, Anne T.
Couppé, Christian
Magnusson, S. Peter
Kjaer, Michael
Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults
title Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults
title_full Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults
title_fullStr Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults
title_full_unstemmed Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults
title_short Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults
title_sort load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357404/
https://www.ncbi.nlm.nih.gov/pubmed/30704412
http://dx.doi.org/10.1186/s12877-019-1043-0
work_keys_str_mv AT eriksenchristians loadmagnitudeaffectspatellartendonmechanicalpropertiesbutnotcollagenorcollagencrosslinkingafterlongtermstrengthtraininginolderadults
AT svenssonreneb loadmagnitudeaffectspatellartendonmechanicalpropertiesbutnotcollagenorcollagencrosslinkingafterlongtermstrengthtraininginolderadults
AT gyllingannet loadmagnitudeaffectspatellartendonmechanicalpropertiesbutnotcollagenorcollagencrosslinkingafterlongtermstrengthtraininginolderadults
AT couppechristian loadmagnitudeaffectspatellartendonmechanicalpropertiesbutnotcollagenorcollagencrosslinkingafterlongtermstrengthtraininginolderadults
AT magnussonspeter loadmagnitudeaffectspatellartendonmechanicalpropertiesbutnotcollagenorcollagencrosslinkingafterlongtermstrengthtraininginolderadults
AT kjaermichael loadmagnitudeaffectspatellartendonmechanicalpropertiesbutnotcollagenorcollagencrosslinkingafterlongtermstrengthtraininginolderadults