Mouse models of porcine circovirus 2 infection

PCV2 is considered the main pathogen of porcine circovirus diseases and porcine circovirus‐associated diseases (PCVD/PCVAD). However, the exact mechanism underlying PCVD/PCVAD is currently unknown. Mouse models of PCV2 are valuable experimental tools that can shed light on the pathogenesis of infect...

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Autores principales: Ouyang, Ting, Liu, Xiao‐hui, Ouyang, Hong‐sheng, Ren, Lin‐zhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357427/
https://www.ncbi.nlm.nih.gov/pubmed/30891543
http://dx.doi.org/10.1002/ame2.12009
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author Ouyang, Ting
Liu, Xiao‐hui
Ouyang, Hong‐sheng
Ren, Lin‐zhu
author_facet Ouyang, Ting
Liu, Xiao‐hui
Ouyang, Hong‐sheng
Ren, Lin‐zhu
author_sort Ouyang, Ting
collection PubMed
description PCV2 is considered the main pathogen of porcine circovirus diseases and porcine circovirus‐associated diseases (PCVD/PCVAD). However, the exact mechanism underlying PCVD/PCVAD is currently unknown. Mouse models of PCV2 are valuable experimental tools that can shed light on the pathogenesis of infection and will enable the evaluation of antiviral agents and vaccine candidates. In this review, we discuss the current state of knowledge of mouse models used in PCV2 research that has been performed to date, highlighting their strengths and limitations, as well as prospects for future PCV2 studies.
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spelling pubmed-63574272019-03-19 Mouse models of porcine circovirus 2 infection Ouyang, Ting Liu, Xiao‐hui Ouyang, Hong‐sheng Ren, Lin‐zhu Animal Model Exp Med Review Articles PCV2 is considered the main pathogen of porcine circovirus diseases and porcine circovirus‐associated diseases (PCVD/PCVAD). However, the exact mechanism underlying PCVD/PCVAD is currently unknown. Mouse models of PCV2 are valuable experimental tools that can shed light on the pathogenesis of infection and will enable the evaluation of antiviral agents and vaccine candidates. In this review, we discuss the current state of knowledge of mouse models used in PCV2 research that has been performed to date, highlighting their strengths and limitations, as well as prospects for future PCV2 studies. John Wiley and Sons Inc. 2018-04-19 /pmc/articles/PMC6357427/ /pubmed/30891543 http://dx.doi.org/10.1002/ame2.12009 Text en © 2018 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Ouyang, Ting
Liu, Xiao‐hui
Ouyang, Hong‐sheng
Ren, Lin‐zhu
Mouse models of porcine circovirus 2 infection
title Mouse models of porcine circovirus 2 infection
title_full Mouse models of porcine circovirus 2 infection
title_fullStr Mouse models of porcine circovirus 2 infection
title_full_unstemmed Mouse models of porcine circovirus 2 infection
title_short Mouse models of porcine circovirus 2 infection
title_sort mouse models of porcine circovirus 2 infection
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357427/
https://www.ncbi.nlm.nih.gov/pubmed/30891543
http://dx.doi.org/10.1002/ame2.12009
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