IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study

OBJECTIVES: An important limitation in granulomatosis with polyangiitis (GPA) is the lack of disease activity markers. Immunoglobulin G4-positive (IgG4(+)) B cells and plasma cells are implicated in the pathogenesis of GPA. We hypothesized that the presence of these cells in peripheral blood could s...

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Detalles Bibliográficos
Autores principales: Al-Soudi, A., Doorenspleet, M. E., Esveldt, R. E., Burgemeister, L. T., Hak, A. E., van den Born, B. J. H., Tas, S. W., van Vollenhoven, R. F., Klarenbeek, P. L., de Vries, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357433/
https://www.ncbi.nlm.nih.gov/pubmed/30704507
http://dx.doi.org/10.1186/s13075-018-1806-6

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