Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Compounds targeting the circadian clock have been identified as potential treatments for clock-related diseases, including cancer. Our cell-based phenotypic screen revealed uncharacterized clock-modulating compounds. Through affinity-based target deconvolution, we identified GO289, which strongly le...

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Detalles Bibliográficos
Autores principales: Oshima, Tsuyoshi, Niwa, Yoshimi, Kuwata, Keiko, Srivastava, Ashutosh, Hyoda, Tomoko, Tsuchiya, Yoshiki, Kumagai, Megumi, Tsuyuguchi, Masato, Tamaru, Teruya, Sugiyama, Akiko, Ono, Natsuko, Zolboot, Norjin, Aikawa, Yoshiki, Oishi, Shunsuke, Nonami, Atsushi, Arai, Fumio, Hagihara, Shinya, Yamaguchi, Junichiro, Tama, Florence, Kunisaki, Yuya, Yagita, Kazuhiro, Ikeda, Masaaki, Kinoshita, Takayoshi, Kay, Steve A., Itami, Kenichiro, Hirota, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357737/
https://www.ncbi.nlm.nih.gov/pubmed/30746467
http://dx.doi.org/10.1126/sciadv.aau9060

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