Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s disease patients. Toxic proteases from the bacterium called gingipains were also identified in the brain of Alzheimer’s patients, and levels correlated with tau and ubiquitin patholog...

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Detalles Bibliográficos
Autores principales: Dominy, Stephen S., Lynch, Casey, Ermini, Florian, Benedyk, Malgorzata, Marczyk, Agata, Konradi, Andrei, Nguyen, Mai, Haditsch, Ursula, Raha, Debasish, Griffin, Christina, Holsinger, Leslie J., Arastu-Kapur, Shirin, Kaba, Samer, Lee, Alexander, Ryder, Mark I., Potempa, Barbara, Mydel, Piotr, Hellvard, Annelie, Adamowicz, Karina, Hasturk, Hatice, Walker, Glenn D., Reynolds, Eric C., Faull, Richard L. M., Curtis, Maurice A., Dragunow, Mike, Potempa, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357742/
https://www.ncbi.nlm.nih.gov/pubmed/30746447
http://dx.doi.org/10.1126/sciadv.aau3333

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