NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated Carcinogenesis

Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host immune response including epithelial and immune cells. The association of NOD2 mutations with a number of inflammato...

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Detalles Bibliográficos
Autores principales: Ferrand, Audrey, Al Nabhani, Ziad, Tapias, Núria Solà, Mas, Emmanuel, Hugot, Jean-Pierre, Barreau, Frédérick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357788/
https://www.ncbi.nlm.nih.gov/pubmed/30704984
http://dx.doi.org/10.1016/j.jcmgh.2018.10.009
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author Ferrand, Audrey
Al Nabhani, Ziad
Tapias, Núria Solà
Mas, Emmanuel
Hugot, Jean-Pierre
Barreau, Frédérick
author_facet Ferrand, Audrey
Al Nabhani, Ziad
Tapias, Núria Solà
Mas, Emmanuel
Hugot, Jean-Pierre
Barreau, Frédérick
author_sort Ferrand, Audrey
collection PubMed
description Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host immune response including epithelial and immune cells. The association of NOD2 mutations with a number of inflammatory pathologies including Crohn’s disease (CD), graft-versus-host diseases, or Blau syndrome, highlights its pivotal role in inflammatory response and the associated-carcinogenesis development. Since its identification in 2001 and its association with CD, the role of NOD2 in epithelial cells and immune cells has been investigated extensively but the precise mechanism by which NOD2 mutations lead to CD and the associated carcinogenesis development is largely unknown. In this review, we present and discuss recent developments about the role of NOD2 inside epithelial cells on the control of the inflammatory process and its linked carcinogenesis development.
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spelling pubmed-63577882019-02-08 NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated Carcinogenesis Ferrand, Audrey Al Nabhani, Ziad Tapias, Núria Solà Mas, Emmanuel Hugot, Jean-Pierre Barreau, Frédérick Cell Mol Gastroenterol Hepatol Review Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host immune response including epithelial and immune cells. The association of NOD2 mutations with a number of inflammatory pathologies including Crohn’s disease (CD), graft-versus-host diseases, or Blau syndrome, highlights its pivotal role in inflammatory response and the associated-carcinogenesis development. Since its identification in 2001 and its association with CD, the role of NOD2 in epithelial cells and immune cells has been investigated extensively but the precise mechanism by which NOD2 mutations lead to CD and the associated carcinogenesis development is largely unknown. In this review, we present and discuss recent developments about the role of NOD2 inside epithelial cells on the control of the inflammatory process and its linked carcinogenesis development. Elsevier 2018-10-23 /pmc/articles/PMC6357788/ /pubmed/30704984 http://dx.doi.org/10.1016/j.jcmgh.2018.10.009 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Ferrand, Audrey
Al Nabhani, Ziad
Tapias, Núria Solà
Mas, Emmanuel
Hugot, Jean-Pierre
Barreau, Frédérick
NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated Carcinogenesis
title NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated Carcinogenesis
title_full NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated Carcinogenesis
title_fullStr NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated Carcinogenesis
title_full_unstemmed NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated Carcinogenesis
title_short NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated Carcinogenesis
title_sort nod2 expression in intestinal epithelial cells protects toward the development of inflammation and associated carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357788/
https://www.ncbi.nlm.nih.gov/pubmed/30704984
http://dx.doi.org/10.1016/j.jcmgh.2018.10.009
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