Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High‐Fat Diet

Phosphatidylethanolamine N‐methyltransferase (PEMT) is a hepatic integral membrane protein localized to the endoplasmic reticulum (ER). PEMT catalyzes approximately 30% of hepatic phosphatidylcholine (PC) biosynthesis. Pemt(–/–) mice fed a high‐fat diet (HFD) develop steatohepatitis. Interestingly,...

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Detalles Bibliográficos
Autores principales: Wan, Sereana, Kuipers, Folkert, Havinga, Rick, Ando, Hiromi, Vance, Dennis E., Jacobs, René L., van der Veen, Jelske N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357837/
https://www.ncbi.nlm.nih.gov/pubmed/30766963
http://dx.doi.org/10.1002/hep4.1302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357837/
https://www.ncbi.nlm.nih.gov/pubmed/30766963
http://dx.doi.org/10.1002/hep4.1302

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