Cargando…

Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms

BACKGROUND: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship betw...

Descripción completa

Detalles Bibliográficos
Autores principales: Kakeda, Shingo, Watanabe, Keita, Katsuki, Asuka, Sugimoto, Koichiro, Ueda, Issei, Igata, Natsuki, Kishi, Taro, Iwata, Nakao, Abe, Osamu, Yoshimura, Reiji, Korogi, Yukunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357876/
https://www.ncbi.nlm.nih.gov/pubmed/30774349
http://dx.doi.org/10.2147/NDT.S190268
_version_ 1783391900244377600
author Kakeda, Shingo
Watanabe, Keita
Katsuki, Asuka
Sugimoto, Koichiro
Ueda, Issei
Igata, Natsuki
Kishi, Taro
Iwata, Nakao
Abe, Osamu
Yoshimura, Reiji
Korogi, Yukunori
author_facet Kakeda, Shingo
Watanabe, Keita
Katsuki, Asuka
Sugimoto, Koichiro
Ueda, Issei
Igata, Natsuki
Kishi, Taro
Iwata, Nakao
Abe, Osamu
Yoshimura, Reiji
Korogi, Yukunori
author_sort Kakeda, Shingo
collection PubMed
description BACKGROUND: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. METHODS: Thirty-five drug-naive MDD patients with a first depressive episode and 47 age-and sex-matched healthy subjects underwent diffusion tensor imaging scans and genotyping. The genotype–diagnosis interactions related to WM integrity were evaluated using TBSS for the 17 SNPs. RESULTS: For the anterior thalamic radiation, cingulum, corticospinal tract, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, superior longitudinal fasciculus, uncinate fasciculus, forceps major, and forceps minor, the genotype effect significantly differed between diagnosis groups (P<0.05, family-wise error corrected) in only one SNP, rs301806, in the arginine–glutamic acid dipeptide (RE) repeats (RERE) gene. CONCLUSION: The RERE polymorphism was associated with WM alterations in first-episode and drug-naive MDD patients, which may be at least partially related to the manifestation of MDD. Future studies are needed to explore the gene–environment interactions with regard to individual WM integrity.
format Online
Article
Text
id pubmed-6357876
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-63578762019-02-15 Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms Kakeda, Shingo Watanabe, Keita Katsuki, Asuka Sugimoto, Koichiro Ueda, Issei Igata, Natsuki Kishi, Taro Iwata, Nakao Abe, Osamu Yoshimura, Reiji Korogi, Yukunori Neuropsychiatr Dis Treat Original Research BACKGROUND: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. METHODS: Thirty-five drug-naive MDD patients with a first depressive episode and 47 age-and sex-matched healthy subjects underwent diffusion tensor imaging scans and genotyping. The genotype–diagnosis interactions related to WM integrity were evaluated using TBSS for the 17 SNPs. RESULTS: For the anterior thalamic radiation, cingulum, corticospinal tract, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, superior longitudinal fasciculus, uncinate fasciculus, forceps major, and forceps minor, the genotype effect significantly differed between diagnosis groups (P<0.05, family-wise error corrected) in only one SNP, rs301806, in the arginine–glutamic acid dipeptide (RE) repeats (RERE) gene. CONCLUSION: The RERE polymorphism was associated with WM alterations in first-episode and drug-naive MDD patients, which may be at least partially related to the manifestation of MDD. Future studies are needed to explore the gene–environment interactions with regard to individual WM integrity. Dove Medical Press 2019-01-29 /pmc/articles/PMC6357876/ /pubmed/30774349 http://dx.doi.org/10.2147/NDT.S190268 Text en © 2019 Kakeda et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Kakeda, Shingo
Watanabe, Keita
Katsuki, Asuka
Sugimoto, Koichiro
Ueda, Issei
Igata, Natsuki
Kishi, Taro
Iwata, Nakao
Abe, Osamu
Yoshimura, Reiji
Korogi, Yukunori
Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms
title Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms
title_full Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms
title_fullStr Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms
title_full_unstemmed Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms
title_short Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms
title_sort genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357876/
https://www.ncbi.nlm.nih.gov/pubmed/30774349
http://dx.doi.org/10.2147/NDT.S190268
work_keys_str_mv AT kakedashingo geneticeffectsonwhitematterintegrityindrugnaivepatientswithmajordepressivedisorderadiffusiontensorimagingstudyof17geneticlociassociatedwithdepressivesymptoms
AT watanabekeita geneticeffectsonwhitematterintegrityindrugnaivepatientswithmajordepressivedisorderadiffusiontensorimagingstudyof17geneticlociassociatedwithdepressivesymptoms
AT katsukiasuka geneticeffectsonwhitematterintegrityindrugnaivepatientswithmajordepressivedisorderadiffusiontensorimagingstudyof17geneticlociassociatedwithdepressivesymptoms
AT sugimotokoichiro geneticeffectsonwhitematterintegrityindrugnaivepatientswithmajordepressivedisorderadiffusiontensorimagingstudyof17geneticlociassociatedwithdepressivesymptoms
AT uedaissei geneticeffectsonwhitematterintegrityindrugnaivepatientswithmajordepressivedisorderadiffusiontensorimagingstudyof17geneticlociassociatedwithdepressivesymptoms
AT igatanatsuki geneticeffectsonwhitematterintegrityindrugnaivepatientswithmajordepressivedisorderadiffusiontensorimagingstudyof17geneticlociassociatedwithdepressivesymptoms
AT kishitaro geneticeffectsonwhitematterintegrityindrugnaivepatientswithmajordepressivedisorderadiffusiontensorimagingstudyof17geneticlociassociatedwithdepressivesymptoms
AT iwatanakao geneticeffectsonwhitematterintegrityindrugnaivepatientswithmajordepressivedisorderadiffusiontensorimagingstudyof17geneticlociassociatedwithdepressivesymptoms
AT abeosamu geneticeffectsonwhitematterintegrityindrugnaivepatientswithmajordepressivedisorderadiffusiontensorimagingstudyof17geneticlociassociatedwithdepressivesymptoms
AT yoshimurareiji geneticeffectsonwhitematterintegrityindrugnaivepatientswithmajordepressivedisorderadiffusiontensorimagingstudyof17geneticlociassociatedwithdepressivesymptoms
AT korogiyukunori geneticeffectsonwhitematterintegrityindrugnaivepatientswithmajordepressivedisorderadiffusiontensorimagingstudyof17geneticlociassociatedwithdepressivesymptoms