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Prognostic role of early D-dimer level in patients with acute ischemic stroke

OBJECT: The purpose of our study was to assess the prognostic role of early D-dimer level in patients with acute ischemic stroke (AIS). METHODS: The included patients’ D-dimer levels have to be tested within 24 hours from stroke onset. Poor functional outcome was defined as modified Rankin Scale (mR...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Liu, Lin, Tao, Jie, Song, Yanlin, Fan, Yimeng, Gou, Maling, Xu, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358072/
https://www.ncbi.nlm.nih.gov/pubmed/30707716
http://dx.doi.org/10.1371/journal.pone.0211458
Descripción
Sumario:OBJECT: The purpose of our study was to assess the prognostic role of early D-dimer level in patients with acute ischemic stroke (AIS). METHODS: The included patients’ D-dimer levels have to be tested within 24 hours from stroke onset. Poor functional outcome was defined as modified Rankin Scale (mRS) ≥3. The endpoints included recurrence on 5-day diffusion-weighted imaging, 30-day mRS ≥3, 30-day mortality and 90-day mRS ≥3. Regarding to each endpoint, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the prognostic role of D-dimer in patients with AIS. RESULTS: A total of 2,479 patients were included. The results showed that elevated D-dimer levels were associated with recurrence on 5-day diffusion-weighted imaging (OR = 2.28, 95% CI = 1.32–3.95), 30-day mRS≥3 (OR = 1.59, 95% CI = 1.37–1.85), 30-day mortality (OR = 1.92, 95% CI = 1.27–2.90) and 90-day mRS≥3 (OR = 1.61, 95% CI = 1.05–2.46). CONCLUSIONS: In conclusion, for patients with AIS, higher D-dimer level within 24 hours from stroke onset was associated with recurrence on 5-day diffusion-weighted imaging, mortality at 30 days, and poor functional outcome at both 30 days and 90 days. However, more studies are warranted to clarify this issue.