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Axial length and its associations in a Russian population: The Ural Eye and Medical Study

PURPOSE: To assess the normal distribution of axial length and its associations in a population of Russia. METHODS: The population-based Ural Eye and Medical Study included 5,899 (80.5%) individuals out of 7328 eligible individuals aged 40+ years. The participants underwent an ocular and systemic ex...

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Autores principales: Bikbov, Mukharram M., Kazakbaeva, Gyulli M., Gilmanshin, Timur R., Zainullin, Rinat M., Arslangareeva, Inga I., Salavatova, Venera F., Bikbova, Guzel M., Panda-Jonas, Songhomitra, Nikitin, Nikolai A., Zaynetdinov, Artur F., Nuriev, Ildar F., Khikmatullin, Renat I., Uzianbaeva, Yulia V., Yakupova, Dilya F., Aminev, Said K., Jonas, Jost B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358075/
https://www.ncbi.nlm.nih.gov/pubmed/30707718
http://dx.doi.org/10.1371/journal.pone.0211186
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author Bikbov, Mukharram M.
Kazakbaeva, Gyulli M.
Gilmanshin, Timur R.
Zainullin, Rinat M.
Arslangareeva, Inga I.
Salavatova, Venera F.
Bikbova, Guzel M.
Panda-Jonas, Songhomitra
Nikitin, Nikolai A.
Zaynetdinov, Artur F.
Nuriev, Ildar F.
Khikmatullin, Renat I.
Uzianbaeva, Yulia V.
Yakupova, Dilya F.
Aminev, Said K.
Jonas, Jost B.
author_facet Bikbov, Mukharram M.
Kazakbaeva, Gyulli M.
Gilmanshin, Timur R.
Zainullin, Rinat M.
Arslangareeva, Inga I.
Salavatova, Venera F.
Bikbova, Guzel M.
Panda-Jonas, Songhomitra
Nikitin, Nikolai A.
Zaynetdinov, Artur F.
Nuriev, Ildar F.
Khikmatullin, Renat I.
Uzianbaeva, Yulia V.
Yakupova, Dilya F.
Aminev, Said K.
Jonas, Jost B.
author_sort Bikbov, Mukharram M.
collection PubMed
description PURPOSE: To assess the normal distribution of axial length and its associations in a population of Russia. METHODS: The population-based Ural Eye and Medical Study included 5,899 (80.5%) individuals out of 7328 eligible individuals aged 40+ years. The participants underwent an ocular and systemic examination. Axial length was measured sonographically (Ultra-compact A/B/P ultrasound system, Quantel Medical, Cournon d'Auvergne, France). RESULTS: Biometric data were available for 5707 (96.7%) individuals with a mean age of 58.8±10.6 years (range:40–94 years; 25%, 50%, 75% quartile: 51.0, 58.0, 66.0 years, respectively). Mean axial length was 23.30±1.10 mm (range: 19.02–32.87mm; 95% confidence interval (CI): 21.36–25.89; 25%, 50%, 75% quartile: 22.65mm, 23.23mm, 23.88mm, resp.). Prevalences of moderate myopia (axial length:24.5-<26.5mm) and high myopia (axial length >26.5mm) were 555/5707 (8.7%;95%CI:9.0,10.5) and 78/5707 (1.4%;95%CI:1.1,1.7), respectively. Longer axial length (mean:23.30±1.10mm) was associated (correlation coefficient r(2):0.70) with older age (P<0.001;standardized regression coefficient beta:0.14), taller body height (P<0.001;beta:0.07), higher level of education (P<0.001;beta:0.04), higher intraocular pressure (P<0.001;beta:0.03), more myopic spherical refractive error (P<0.001;beta:-0.55), lower corneal refractive power (P<0.001;beta:-0.44), deeper anterior chamber depth (P<0.001;beta:0.20), wider anterior chamber angle (P<0.001;beta:0.05), thinner peripapillary retinal nerve fiber layer thickness (P<0.001;beta:-0.04), higher degree of macular fundus tessellation (P<0.001;beta:0.08), lower prevalence of epiretinal membranes (P = 0.01;beta-0.02) and pseudoexfoliation (P = 0.007;beta:-0.02) and higher prevalence of myopic maculopathy (P<0.001;beta:0.08). In that model, prevalence of age-related macular degeneration (any type: P = 0.84; early type: P = 0.46), diabetic retinopathy (P = 0.16), and region of habitation (P = 0.27) were not significantly associated with axial length. CONCLUSIONS: Mean axial length in this typically multi-ethnic Russian study population was comparable with values from populations in Singapore and Beijing. In contrast to previous studies, axial length was not significantly related with the prevalences of age-related macular degeneration and diabetic retinopathy or region of habitation.
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spelling pubmed-63580752019-02-15 Axial length and its associations in a Russian population: The Ural Eye and Medical Study Bikbov, Mukharram M. Kazakbaeva, Gyulli M. Gilmanshin, Timur R. Zainullin, Rinat M. Arslangareeva, Inga I. Salavatova, Venera F. Bikbova, Guzel M. Panda-Jonas, Songhomitra Nikitin, Nikolai A. Zaynetdinov, Artur F. Nuriev, Ildar F. Khikmatullin, Renat I. Uzianbaeva, Yulia V. Yakupova, Dilya F. Aminev, Said K. Jonas, Jost B. PLoS One Research Article PURPOSE: To assess the normal distribution of axial length and its associations in a population of Russia. METHODS: The population-based Ural Eye and Medical Study included 5,899 (80.5%) individuals out of 7328 eligible individuals aged 40+ years. The participants underwent an ocular and systemic examination. Axial length was measured sonographically (Ultra-compact A/B/P ultrasound system, Quantel Medical, Cournon d'Auvergne, France). RESULTS: Biometric data were available for 5707 (96.7%) individuals with a mean age of 58.8±10.6 years (range:40–94 years; 25%, 50%, 75% quartile: 51.0, 58.0, 66.0 years, respectively). Mean axial length was 23.30±1.10 mm (range: 19.02–32.87mm; 95% confidence interval (CI): 21.36–25.89; 25%, 50%, 75% quartile: 22.65mm, 23.23mm, 23.88mm, resp.). Prevalences of moderate myopia (axial length:24.5-<26.5mm) and high myopia (axial length >26.5mm) were 555/5707 (8.7%;95%CI:9.0,10.5) and 78/5707 (1.4%;95%CI:1.1,1.7), respectively. Longer axial length (mean:23.30±1.10mm) was associated (correlation coefficient r(2):0.70) with older age (P<0.001;standardized regression coefficient beta:0.14), taller body height (P<0.001;beta:0.07), higher level of education (P<0.001;beta:0.04), higher intraocular pressure (P<0.001;beta:0.03), more myopic spherical refractive error (P<0.001;beta:-0.55), lower corneal refractive power (P<0.001;beta:-0.44), deeper anterior chamber depth (P<0.001;beta:0.20), wider anterior chamber angle (P<0.001;beta:0.05), thinner peripapillary retinal nerve fiber layer thickness (P<0.001;beta:-0.04), higher degree of macular fundus tessellation (P<0.001;beta:0.08), lower prevalence of epiretinal membranes (P = 0.01;beta-0.02) and pseudoexfoliation (P = 0.007;beta:-0.02) and higher prevalence of myopic maculopathy (P<0.001;beta:0.08). In that model, prevalence of age-related macular degeneration (any type: P = 0.84; early type: P = 0.46), diabetic retinopathy (P = 0.16), and region of habitation (P = 0.27) were not significantly associated with axial length. CONCLUSIONS: Mean axial length in this typically multi-ethnic Russian study population was comparable with values from populations in Singapore and Beijing. In contrast to previous studies, axial length was not significantly related with the prevalences of age-related macular degeneration and diabetic retinopathy or region of habitation. Public Library of Science 2019-02-01 /pmc/articles/PMC6358075/ /pubmed/30707718 http://dx.doi.org/10.1371/journal.pone.0211186 Text en © 2019 Bikbov et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bikbov, Mukharram M.
Kazakbaeva, Gyulli M.
Gilmanshin, Timur R.
Zainullin, Rinat M.
Arslangareeva, Inga I.
Salavatova, Venera F.
Bikbova, Guzel M.
Panda-Jonas, Songhomitra
Nikitin, Nikolai A.
Zaynetdinov, Artur F.
Nuriev, Ildar F.
Khikmatullin, Renat I.
Uzianbaeva, Yulia V.
Yakupova, Dilya F.
Aminev, Said K.
Jonas, Jost B.
Axial length and its associations in a Russian population: The Ural Eye and Medical Study
title Axial length and its associations in a Russian population: The Ural Eye and Medical Study
title_full Axial length and its associations in a Russian population: The Ural Eye and Medical Study
title_fullStr Axial length and its associations in a Russian population: The Ural Eye and Medical Study
title_full_unstemmed Axial length and its associations in a Russian population: The Ural Eye and Medical Study
title_short Axial length and its associations in a Russian population: The Ural Eye and Medical Study
title_sort axial length and its associations in a russian population: the ural eye and medical study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358075/
https://www.ncbi.nlm.nih.gov/pubmed/30707718
http://dx.doi.org/10.1371/journal.pone.0211186
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