Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial

BACKGROUND: Up to 60% of patients with Crohn's disease need intestinal resection within the first 10 years of diagnosis, and postoperative recurrence is common. We investigated whether mercaptopurine can prevent or delay postoperative clinical recurrence of Crohn's disease. METHODS: We did...

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Detalles Bibliográficos
Autores principales: Mowat, Craig, Arnott, Ian, Cahill, Aiden, Smith, Malcolm, Ahmad, Tariq, Subramanian, Sreedhar, Travis, Simon, Morris, John, Hamlin, John, Dhar, Anjan, Nwokolo, Chuka, Edwards, Cathryn, Creed, Tom, Bloom, Stuart, Yousif, Mohamed, Thomas, Linzi, Campbell, Simon, Lewis, Stephen J, Sebastian, Shaji, Sen, Sandip, Lal, Simon, Hawkey, Chris, Murray, Charles, Cummings, Fraser, Goh, Jason, Lindsay, James O, Arebi, Naila, Potts, Lindsay, McKinley, Aileen J, Thomson, John M, Todd, John A, Collie, Mhairi, Dunlop, Malcolm G, Mowat, Ashley, Gaya, Daniel R, Winter, Jack, Naismith, Graham D, Ennis, Holly, Keerie, Catriona, Lewis, Steff, Prescott, Robin J, Kennedy, Nicholas A, Satsangi, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358144/
https://www.ncbi.nlm.nih.gov/pubmed/28404197
http://dx.doi.org/10.1016/S2468-1253(16)30078-4

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