Rationalizing Secondary Pharmacology Screening Using Human Genetic and Pharmacological Evidence

Safety-related drug failures remain a major challenge for the pharmaceutical industry. One approach to ensuring drug safety involves assessing small molecule drug specificity by examining the ability of a drug candidate to interact with a panel of “off-target” proteins, referred to as secondary phar...

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Detalles Bibliográficos
Autores principales: Deaton, Aimee M, Fan, Fan, Zhang, Wei, Nguyen, Phuong A, Ward, Lucas D, Nioi, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Secondary Pharmacology Screening with Human Evidence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358245/
https://www.ncbi.nlm.nih.gov/pubmed/30346593
http://dx.doi.org/10.1093/toxsci/kfy265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358245/
https://www.ncbi.nlm.nih.gov/pubmed/30346593
http://dx.doi.org/10.1093/toxsci/kfy265

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