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Rationalizing Secondary Pharmacology Screening Using Human Genetic and Pharmacological Evidence
Safety-related drug failures remain a major challenge for the pharmaceutical industry. One approach to ensuring drug safety involves assessing small molecule drug specificity by examining the ability of a drug candidate to interact with a panel of “off-target” proteins, referred to as secondary phar...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358245/ https://www.ncbi.nlm.nih.gov/pubmed/30346593 http://dx.doi.org/10.1093/toxsci/kfy265 |