Cargando…

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

TAK-875 (fasiglifam), a GPR40 agonist in development for the treatment of type 2 diabetes (T2D), was voluntarily terminated in Phase III trials due to adverse liver effects. The potential mechanisms of TAK-875 toxicity were explored by combining in vitro experiments with quantitative systems toxicol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Longo, Diane M, Woodhead, Jeffrey L, Walker, Paul, Herédi-Szabó, Krisztina, Mogyorósi, Károly, Wolenski, Francis S, Dragan, Yvonne P, Mosedale, Merrie, Siler, Scott Q, Watkins, Paul B, Howell, Brett A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Tak-875 Liver Injury: Bile Acid and Mitochondrial Effects
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358270/ https://www.ncbi.nlm.nih.gov/pubmed/30289550 http://dx.doi.org/10.1093/toxsci/kfy253

Ejemplares similares

Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury
por: Wolenski, Francis S., et al.
Publicado: (2017)

AVALIAÇÃO DAS SUBPOPULAÇÕES LINFOCITÁRIAS T, B E NK EM PACIENTES COM COVID-19 GRAVE ATENDIDOS EM UM HOSPITAL UNIVERSITÁRIO
por: Oliveira, D.C., et al.
Publicado: (2020)

Lung Transplantation during COVID19 Pandemic: Latam Experience
por: Bertolotti, A.M., et al.
Publicado: (2021)

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors
por: Woodhead, Jeffrey L., et al.
Publicado: (2017)

Metabolic manipulators: a well founded strategy to combat mitochondrial dysfunction
por: Koene, Saskia, et al.
Publicado: (2010)

Biochemical diagnosis of mitochondrial disorders
por: Rodenburg, Richard J. T.
Publicado: (2010)

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency
por: Martinez Lyons, Anabel, et al.
Publicado: (2016)

Anticonvulsant Medications in Mitochondrial Disease
por: Mithal, Divakar S., et al.
Publicado: (2017)

De novo mtDNA point mutations are common and have a low recurrence risk
por: Sallevelt, Suzanne C E H, et al.
Publicado: (2017)

Increased protein propionylation contributes to mitochondrial dysfunction in liver cells and fibroblasts, but not in myotubes
por: Lagerwaard, Bart, et al.
Publicado: (2020)

AGING IN PLACE: EFFECTIVE INTERPROFESSIONAL COLLABORATION AND ENGAGEMENT WITH OLDER ADULTS
por: Fine-Smilovich, Elizabeth, et al.
Publicado: (2019)

THE FALL OF THE BERLIN WALL AND STEREOTYPES OF AGING: AN INTERGENERATIONAL STUDY ABROAD EXPERIENCE
por: Macaluso, Suzie
Publicado: (2019)

Hepatic Histological Findings in Suspected Drug-Induced Liver Injury: Systematic Evaluation and Clinical Associations
por: Kleiner, David E, et al.
Publicado: (2014)

Inhibition of RelA-Ser536 Phosphorylation by a Competing Peptide Reduces Mouse Liver Fibrosis Without Blocking the Innate Immune Response
por: Moles, Anna, et al.
Publicado: (2013)

Endogenous Histones Function as Alarmins in Sterile Inflammatory Liver Injury Through Toll-like Receptor 9 in Mice
por: Huang, Hai, et al.
Publicado: (2011)

Yes-Associated Protein Regulates the Hepatic Response After Bile Duct Ligation
por: Bai, Haibo, et al.
Publicado: (2012)

Noninvasive in vivo magnetic resonance measures of glutathione synthesis in human and rat liver as an oxidative stress biomarker
por: Skamarauskas, John T, et al.
Publicado: (2014)

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital
por: Antoine, Daniel J, et al.
Publicado: (2013)

Mesenchymal Stem Cells Alleviate Bacteria-Induced Liver Injury in Mice by Inducing Regulatory Dendritic Cells
por: Zhang, Yi, et al.
Publicado: (2014)

Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells
por: Dianat, Noushin, et al.
Publicado: (2014)

Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen‐Induced Liver Injury
por: Antoine, Daniel J., et al.
Publicado: (2015)

Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen‐activated protein kinase phosphatase‐1
por: Wang, Jie, et al.
Publicado: (2016)

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug‐induced liver injury and postinjury inflammation in mice
por: Lundbäck, Peter, et al.
Publicado: (2016)

Anisotropic diffusion of fluorescently labeled ATP in rat cardiomyocytes determined by raster image correlation spectroscopy
por: Vendelin, Marko, et al.
Publicado: (2008)

Pyruvate suppresses PGC1α expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes
por: Philp, Andrew, et al.
Publicado: (2010)

Dysregulation of l-arginine metabolism and bioavailability associated to free plasma heme
por: Omodeo-Salè, F., et al.
Publicado: (2010)

A Novel Antidiabetic Drug, Fasiglifam/TAK-875, Acts as an Ago-Allosteric Modulator of FFAR1
por: Yabuki, Chiori, et al.
Publicado: (2013)

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling
por: Woodhead, Jeffrey L, et al.
Publicado: (2022)

Development of pharmacological strategies for mitochondrial disorders
por: Kanabus, M, et al.
Publicado: (2014)

Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease
por: Hall, A R, et al.
Publicado: (2014)

Unravelling mitochondrial pathways to Parkinson's disease
por: Celardo, I, et al.
Publicado: (2014)

Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration
por: Osellame, L D, et al.
Publicado: (2014)

A high molar activity (18)F-labeled TAK-875 derivative for PET imaging of pancreatic β-cells
por: Dornan, Mark H., et al.
Publicado: (2018)

Guideline review: EASL clinical practice guidelines: drug-induced liver injury (DILI)
por: Brennan, Paul N, et al.
Publicado: (2021)

A new diagnostic indication device of a biomarker growth differentiation factor 15 for mitochondrial diseases: From laboratory to automated inspection
por: Koga, Yasutoshi, et al.
Publicado: (2020)

Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects With Type 2 Diabetes Mellitus
por: Naik, H, et al.
Publicado: (2013)

Real-world evidence of long-term survival and healthcare resource use in patients with hepatic encephalopathy receiving rifaximin-α treatment: a retrospective observational extension study with long-term follow-up (IMPRESS II)
por: Aspinall, Richard J, et al.
Publicado: (2022)

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling
por: Woodhead, Jeffrey L., et al.
Publicado: (2019)

The impact of rifaximin-α on the hospital resource use associated with the management of patients with hepatic encephalopathy: a retrospective observational study (IMPRESS)
por: Hudson, Mark, et al.
Publicado: (2017)

TAK-875 Mitigates β-Cell Lipotoxicity-Induced Metaflammation Damage through Inhibiting the TLR4-NF-κB Pathway
por: Chen, Xide, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_d5pdfbrm05srrj4a8614gl2j51