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Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model
Down Syndrome (DS), the most common cause of genetic intellectual disability, is characterized by over-expression of the APP and DYRK1A genes, located on the triplicated chromosome 21. This chromosomal abnormality leads to a cognitive decline mediated by Amyloid-β (Aβ) overproduction and tau hyper-p...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358279/ https://www.ncbi.nlm.nih.gov/pubmed/30389461 http://dx.doi.org/10.1016/j.bbi.2018.10.004 |