Relationship between geometric changes in mitral annular/leaflets and mitral regurgitation in patients with atrial fibrillation

The objective of the study was to determine the geometric changes in mitral annular and/or leaflets spatial conformation in patients with atrial fibrillation (AF) complicated with severe atrial mitral regurgitation (AMR) by using real-time 3-dimensional transesophageal echocardiography, aiming to ex...

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Autores principales: Chen, Xiaofeng, Li, Hua, Feng, Zhenhua, Tang, Sha, Song, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358411/
https://www.ncbi.nlm.nih.gov/pubmed/30681567
http://dx.doi.org/10.1097/MD.0000000000014090
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author Chen, Xiaofeng
Li, Hua
Feng, Zhenhua
Tang, Sha
Song, Lei
author_facet Chen, Xiaofeng
Li, Hua
Feng, Zhenhua
Tang, Sha
Song, Lei
author_sort Chen, Xiaofeng
collection PubMed
description The objective of the study was to determine the geometric changes in mitral annular and/or leaflets spatial conformation in patients with atrial fibrillation (AF) complicated with severe atrial mitral regurgitation (AMR) by using real-time 3-dimensional transesophageal echocardiography, aiming to explore whether this condition could be improved through self-modulation of mitral annulus and/or leaflets after the restoration of sinus rhythm. Fifty-five patients who were diagnosed with AMR and subject to 1-year follow-up were recruited in this clinical trial. All patients successfully received AF ablation. The intercommissural and anteroposterior diameter, annular height, mitral valve area (MVA), tenting height and volume, annular spherical index, fractional area change of MVA (MVA-FAC), and coaptation index (CP-I) were defined and measured by mitral-valve quantification software. Left ventricular size and function, maximum LA volume (LAV), and LA dimensions were equally recorded. During 1-year follow-up, AMR was significantly decreased in patients with sinus rhythm (P < 0.001). CP-I, MVA-FAC, and LAV index were independently associated with the reduction of AMR. AMR can be improved through the recovery of LAV after ablation, which probably affects the configuration of the annular space and the coaptation of the leaflets.
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spelling pubmed-63584112019-02-15 Relationship between geometric changes in mitral annular/leaflets and mitral regurgitation in patients with atrial fibrillation Chen, Xiaofeng Li, Hua Feng, Zhenhua Tang, Sha Song, Lei Medicine (Baltimore) Research Article The objective of the study was to determine the geometric changes in mitral annular and/or leaflets spatial conformation in patients with atrial fibrillation (AF) complicated with severe atrial mitral regurgitation (AMR) by using real-time 3-dimensional transesophageal echocardiography, aiming to explore whether this condition could be improved through self-modulation of mitral annulus and/or leaflets after the restoration of sinus rhythm. Fifty-five patients who were diagnosed with AMR and subject to 1-year follow-up were recruited in this clinical trial. All patients successfully received AF ablation. The intercommissural and anteroposterior diameter, annular height, mitral valve area (MVA), tenting height and volume, annular spherical index, fractional area change of MVA (MVA-FAC), and coaptation index (CP-I) were defined and measured by mitral-valve quantification software. Left ventricular size and function, maximum LA volume (LAV), and LA dimensions were equally recorded. During 1-year follow-up, AMR was significantly decreased in patients with sinus rhythm (P < 0.001). CP-I, MVA-FAC, and LAV index were independently associated with the reduction of AMR. AMR can be improved through the recovery of LAV after ablation, which probably affects the configuration of the annular space and the coaptation of the leaflets. Wolters Kluwer Health 2019-01-25 /pmc/articles/PMC6358411/ /pubmed/30681567 http://dx.doi.org/10.1097/MD.0000000000014090 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Chen, Xiaofeng
Li, Hua
Feng, Zhenhua
Tang, Sha
Song, Lei
Relationship between geometric changes in mitral annular/leaflets and mitral regurgitation in patients with atrial fibrillation
title Relationship between geometric changes in mitral annular/leaflets and mitral regurgitation in patients with atrial fibrillation
title_full Relationship between geometric changes in mitral annular/leaflets and mitral regurgitation in patients with atrial fibrillation
title_fullStr Relationship between geometric changes in mitral annular/leaflets and mitral regurgitation in patients with atrial fibrillation
title_full_unstemmed Relationship between geometric changes in mitral annular/leaflets and mitral regurgitation in patients with atrial fibrillation
title_short Relationship between geometric changes in mitral annular/leaflets and mitral regurgitation in patients with atrial fibrillation
title_sort relationship between geometric changes in mitral annular/leaflets and mitral regurgitation in patients with atrial fibrillation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358411/
https://www.ncbi.nlm.nih.gov/pubmed/30681567
http://dx.doi.org/10.1097/MD.0000000000014090
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