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Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report

RATIONALE: Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms with only a few reported cases affecting the nasal cavity, paranasal sinuses, and anterior skull base. PATIENT CONCERNS: A 12-year-old girl with a mass in her nose was admitted to the Department of Otorhinolaryngology of...

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Autores principales: Li, Qian, Pan, Hongguang, Li, Lan, Cao, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358413/
https://www.ncbi.nlm.nih.gov/pubmed/30681599
http://dx.doi.org/10.1097/MD.0000000000014223
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author Li, Qian
Pan, Hongguang
Li, Lan
Cao, Juan
author_facet Li, Qian
Pan, Hongguang
Li, Lan
Cao, Juan
author_sort Li, Qian
collection PubMed
description RATIONALE: Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms with only a few reported cases affecting the nasal cavity, paranasal sinuses, and anterior skull base. PATIENT CONCERNS: A 12-year-old girl with a mass in her nose was admitted to the Department of Otorhinolaryngology of Shenzhen Children's Hospital. She had a 4-month history of progressive, unilateral right nasal obstruction, unilateral mucopurulent rhinorrhea, foul nasal odor, snoring, hyposmia, occasional epistaxis, and no headache, no facial numbness, without eye swelling and vision loss. DIAGNOSE: A computed tomography (CT) scan of the paranasal sinuses showed a mass (right inflammatory polyp and calcification) involving the nasal cavity, the right maxillary sinusitis, ethmoid sinusitis. There was no nasal septum, orbital, or skull base involvement. On the basis of pathological and immunohistological findings, the tumor was diagnosed as an MPNST with heterogeneous components (cartilage and bone) mesenchymal differentiation after the operation. INTERVENTIONS: The girl was treated by surgery and chemotherapy. OUTCOMES: The postoperative course was uneventful. There was no recurrence observed during the 3-year follow-up. LESSONS: The primary MPNST in the nasal cavity is rare, if nasal neoplasms do not respond well to vasoconstrictors and glucocorticoids in children, the possibility of a tumor should be considered. If new organisms grow rapidly with hemorrhagic necrosis, the possibility of a malignant tumor is greater.
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spelling pubmed-63584132019-02-15 Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report Li, Qian Pan, Hongguang Li, Lan Cao, Juan Medicine (Baltimore) Research Article RATIONALE: Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms with only a few reported cases affecting the nasal cavity, paranasal sinuses, and anterior skull base. PATIENT CONCERNS: A 12-year-old girl with a mass in her nose was admitted to the Department of Otorhinolaryngology of Shenzhen Children's Hospital. She had a 4-month history of progressive, unilateral right nasal obstruction, unilateral mucopurulent rhinorrhea, foul nasal odor, snoring, hyposmia, occasional epistaxis, and no headache, no facial numbness, without eye swelling and vision loss. DIAGNOSE: A computed tomography (CT) scan of the paranasal sinuses showed a mass (right inflammatory polyp and calcification) involving the nasal cavity, the right maxillary sinusitis, ethmoid sinusitis. There was no nasal septum, orbital, or skull base involvement. On the basis of pathological and immunohistological findings, the tumor was diagnosed as an MPNST with heterogeneous components (cartilage and bone) mesenchymal differentiation after the operation. INTERVENTIONS: The girl was treated by surgery and chemotherapy. OUTCOMES: The postoperative course was uneventful. There was no recurrence observed during the 3-year follow-up. LESSONS: The primary MPNST in the nasal cavity is rare, if nasal neoplasms do not respond well to vasoconstrictors and glucocorticoids in children, the possibility of a tumor should be considered. If new organisms grow rapidly with hemorrhagic necrosis, the possibility of a malignant tumor is greater. Wolters Kluwer Health 2019-01-25 /pmc/articles/PMC6358413/ /pubmed/30681599 http://dx.doi.org/10.1097/MD.0000000000014223 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Li, Qian
Pan, Hongguang
Li, Lan
Cao, Juan
Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report
title Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report
title_full Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report
title_fullStr Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report
title_full_unstemmed Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report
title_short Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report
title_sort malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: a case report
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358413/
https://www.ncbi.nlm.nih.gov/pubmed/30681599
http://dx.doi.org/10.1097/MD.0000000000014223
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