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Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
OBJECTIVE: Structurally-improved GIP analogs were developed to determine precisely whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice. METHODS: A series of peptide-based GIP analogs, including structurally diverse agonists and a long-acting antagonist, were generated...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358549/ https://www.ncbi.nlm.nih.gov/pubmed/30578168 http://dx.doi.org/10.1016/j.molmet.2018.12.001 |