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Beam selection for stereotactic ablative radiotherapy using Cyberknife with multileaf collimation
The Cyberknife system (Accuray Inc., Sunnyvale, CA) enables radiotherapy using stereotactic ablative body radiotherapy (SABR) with a large number of non-coplanar beam orientations. Recently, a multileaf collimator has also been available to allow flexibility in field shaping. This work aims to evalu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Butterworth-Heinemann
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358634/ https://www.ncbi.nlm.nih.gov/pubmed/30579786 http://dx.doi.org/10.1016/j.medengphy.2018.12.011 |
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author | Bedford, James L. Ziegenhein, Peter Nill, Simeon Oelfke, Uwe |
author_facet | Bedford, James L. Ziegenhein, Peter Nill, Simeon Oelfke, Uwe |
author_sort | Bedford, James L. |
collection | PubMed |
description | The Cyberknife system (Accuray Inc., Sunnyvale, CA) enables radiotherapy using stereotactic ablative body radiotherapy (SABR) with a large number of non-coplanar beam orientations. Recently, a multileaf collimator has also been available to allow flexibility in field shaping. This work aims to evaluate the quality of treatment plans obtainable with the multileaf collimator. Specifically, the aim is to find a subset of beam orientations from a predetermined set of candidate directions, such that the treatment quality is maintained but the treatment time is reduced. An evolutionary algorithm is used to successively refine a randomly selected starting set of beam orientations. By using an efficient computational framework, clinically useful solutions can be found in several hours. It is found that 15 beam orientations are able to provide treatment quality which approaches that of the candidate beam set of 110 beam orientations, but with approximately half of the estimated treatment time. Choice of an efficient subset of beam orientations offers the possibility to improve the patient experience and maximise the number of patients treated. |
format | Online Article Text |
id | pubmed-6358634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Butterworth-Heinemann |
record_format | MEDLINE/PubMed |
spelling | pubmed-63586342019-02-14 Beam selection for stereotactic ablative radiotherapy using Cyberknife with multileaf collimation Bedford, James L. Ziegenhein, Peter Nill, Simeon Oelfke, Uwe Med Eng Phys Article The Cyberknife system (Accuray Inc., Sunnyvale, CA) enables radiotherapy using stereotactic ablative body radiotherapy (SABR) with a large number of non-coplanar beam orientations. Recently, a multileaf collimator has also been available to allow flexibility in field shaping. This work aims to evaluate the quality of treatment plans obtainable with the multileaf collimator. Specifically, the aim is to find a subset of beam orientations from a predetermined set of candidate directions, such that the treatment quality is maintained but the treatment time is reduced. An evolutionary algorithm is used to successively refine a randomly selected starting set of beam orientations. By using an efficient computational framework, clinically useful solutions can be found in several hours. It is found that 15 beam orientations are able to provide treatment quality which approaches that of the candidate beam set of 110 beam orientations, but with approximately half of the estimated treatment time. Choice of an efficient subset of beam orientations offers the possibility to improve the patient experience and maximise the number of patients treated. Butterworth-Heinemann 2019-02 /pmc/articles/PMC6358634/ /pubmed/30579786 http://dx.doi.org/10.1016/j.medengphy.2018.12.011 Text en © The Authors. IPEM. Published by Elsevier Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bedford, James L. Ziegenhein, Peter Nill, Simeon Oelfke, Uwe Beam selection for stereotactic ablative radiotherapy using Cyberknife with multileaf collimation |
title | Beam selection for stereotactic ablative radiotherapy using Cyberknife with multileaf collimation |
title_full | Beam selection for stereotactic ablative radiotherapy using Cyberknife with multileaf collimation |
title_fullStr | Beam selection for stereotactic ablative radiotherapy using Cyberknife with multileaf collimation |
title_full_unstemmed | Beam selection for stereotactic ablative radiotherapy using Cyberknife with multileaf collimation |
title_short | Beam selection for stereotactic ablative radiotherapy using Cyberknife with multileaf collimation |
title_sort | beam selection for stereotactic ablative radiotherapy using cyberknife with multileaf collimation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358634/ https://www.ncbi.nlm.nih.gov/pubmed/30579786 http://dx.doi.org/10.1016/j.medengphy.2018.12.011 |
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