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RUNX1-ETO: Attacking the Epigenome for Genomic Instable Leukemia

Oncogenic fusion protein RUNX1-ETO is the product of the t(8;21) translocation, responsible for the most common cytogenetic subtype of acute myeloid leukemia. RUNX1, a critical transcription factor in hematopoietic development, is fused with almost the entire ETO sequence with the ability to recruit...

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Detalles Bibliográficos
Autores principales:	van der Kouwe, Emiel, Staber, Philipp Bernhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358732/ https://www.ncbi.nlm.nih.gov/pubmed/30654457 http://dx.doi.org/10.3390/ijms20020350

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