Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers

Platelet rich plasma (PRP) is blood plasma with a platelet concentration above baseline. When activated, PRP releases growth factors involved in all stages of wound healing, potentially boosting the healing process. To expand our knowledge of the effectiveness of PRP, it is crucial to know the conte...

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Autores principales: Marck, Roos E., Gardien, Kim L. M., Vlig, Marcel, Breederveld, Roelf S., Middelkoop, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358744/
https://www.ncbi.nlm.nih.gov/pubmed/30642068
http://dx.doi.org/10.3390/ijms20020288
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author Marck, Roos E.
Gardien, Kim L. M.
Vlig, Marcel
Breederveld, Roelf S.
Middelkoop, Esther
author_facet Marck, Roos E.
Gardien, Kim L. M.
Vlig, Marcel
Breederveld, Roelf S.
Middelkoop, Esther
author_sort Marck, Roos E.
collection PubMed
description Platelet rich plasma (PRP) is blood plasma with a platelet concentration above baseline. When activated, PRP releases growth factors involved in all stages of wound healing, potentially boosting the healing process. To expand our knowledge of the effectiveness of PRP, it is crucial to know the content and composition of PRP products. In this study, growth factor quantification measurements of PRP from burn patients and gender- and age-matched controls were performed. The PRP of burn patients showed levels of growth factors comparable to those of the PRP of healthy volunteers. Considerable intra-individual variation in growth factor content was found. However, a correlation was found between the platelet count of the PRP and most of the growth factors measured.
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spelling pubmed-63587442019-02-06 Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers Marck, Roos E. Gardien, Kim L. M. Vlig, Marcel Breederveld, Roelf S. Middelkoop, Esther Int J Mol Sci Communication Platelet rich plasma (PRP) is blood plasma with a platelet concentration above baseline. When activated, PRP releases growth factors involved in all stages of wound healing, potentially boosting the healing process. To expand our knowledge of the effectiveness of PRP, it is crucial to know the content and composition of PRP products. In this study, growth factor quantification measurements of PRP from burn patients and gender- and age-matched controls were performed. The PRP of burn patients showed levels of growth factors comparable to those of the PRP of healthy volunteers. Considerable intra-individual variation in growth factor content was found. However, a correlation was found between the platelet count of the PRP and most of the growth factors measured. MDPI 2019-01-12 /pmc/articles/PMC6358744/ /pubmed/30642068 http://dx.doi.org/10.3390/ijms20020288 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Marck, Roos E.
Gardien, Kim L. M.
Vlig, Marcel
Breederveld, Roelf S.
Middelkoop, Esther
Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers
title Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers
title_full Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers
title_fullStr Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers
title_full_unstemmed Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers
title_short Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers
title_sort growth factor quantification of platelet-rich plasma in burn patients compared to matched healthy volunteers
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358744/
https://www.ncbi.nlm.nih.gov/pubmed/30642068
http://dx.doi.org/10.3390/ijms20020288
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