Cargando…
Surface Composition and Preparation Method for Oxygen Nanobubbles for Drug Delivery and Ultrasound Imaging Applications
Phospholipids have been widely investigated for the preparation of liposomes, and micro and nanobubbles. They comprise biocompatible and biodegradable molecules and offer simple preparation with a variety of functions in diagnostic and therapeutic applications. Phospholipids require emulsifiers and...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358755/ https://www.ncbi.nlm.nih.gov/pubmed/30609703 http://dx.doi.org/10.3390/nano9010048 |
_version_ | 1783392057141755904 |
---|---|
author | Khan, Muhammad Saad Hwang, Jangsun Lee, Kyungwoo Choi, Yonghyun Jang, Jaehee Kwon, Yejin Hong, Jong Wook Choi, Jonghoon |
author_facet | Khan, Muhammad Saad Hwang, Jangsun Lee, Kyungwoo Choi, Yonghyun Jang, Jaehee Kwon, Yejin Hong, Jong Wook Choi, Jonghoon |
author_sort | Khan, Muhammad Saad |
collection | PubMed |
description | Phospholipids have been widely investigated for the preparation of liposomes, and micro and nanobubbles. They comprise biocompatible and biodegradable molecules and offer simple preparation with a variety of functions in diagnostic and therapeutic applications. Phospholipids require emulsifiers and surfactants to assemble in the form of bubbles. These surfactants determine the size, zeta potential, and other characteristics of particles. Polyethylene glycol (PEG) and its various derivatives have been employed by researchers to synthesize micro and nanobubbles. The stability of phospholipid-shelled nanobubbles has been reported by various researchers owing to the reduction of surface tension by surfactants in the shell. Nanobubbles have been employed to deliver oxygen to tissues and hypoxic cells. In this study, we investigated the effects of different ratios of phospholipids to PEG on the size, distribution, and characterization of oxygen nanobubbles (ONBs). ONBs were synthesized using a sonication technique. We analyzed and compared the sizes, numbers of generated particles, and zeta potentials of different compositions of ONBs using dynamic light scattering and nanoparticle tracking analysis. Then, we employed these oxygen nanobubbles to enhance the cellular microenvironment and cell viability. ONBs were also investigated for ultrasound imaging. |
format | Online Article Text |
id | pubmed-6358755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63587552019-02-06 Surface Composition and Preparation Method for Oxygen Nanobubbles for Drug Delivery and Ultrasound Imaging Applications Khan, Muhammad Saad Hwang, Jangsun Lee, Kyungwoo Choi, Yonghyun Jang, Jaehee Kwon, Yejin Hong, Jong Wook Choi, Jonghoon Nanomaterials (Basel) Article Phospholipids have been widely investigated for the preparation of liposomes, and micro and nanobubbles. They comprise biocompatible and biodegradable molecules and offer simple preparation with a variety of functions in diagnostic and therapeutic applications. Phospholipids require emulsifiers and surfactants to assemble in the form of bubbles. These surfactants determine the size, zeta potential, and other characteristics of particles. Polyethylene glycol (PEG) and its various derivatives have been employed by researchers to synthesize micro and nanobubbles. The stability of phospholipid-shelled nanobubbles has been reported by various researchers owing to the reduction of surface tension by surfactants in the shell. Nanobubbles have been employed to deliver oxygen to tissues and hypoxic cells. In this study, we investigated the effects of different ratios of phospholipids to PEG on the size, distribution, and characterization of oxygen nanobubbles (ONBs). ONBs were synthesized using a sonication technique. We analyzed and compared the sizes, numbers of generated particles, and zeta potentials of different compositions of ONBs using dynamic light scattering and nanoparticle tracking analysis. Then, we employed these oxygen nanobubbles to enhance the cellular microenvironment and cell viability. ONBs were also investigated for ultrasound imaging. MDPI 2019-01-02 /pmc/articles/PMC6358755/ /pubmed/30609703 http://dx.doi.org/10.3390/nano9010048 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Khan, Muhammad Saad Hwang, Jangsun Lee, Kyungwoo Choi, Yonghyun Jang, Jaehee Kwon, Yejin Hong, Jong Wook Choi, Jonghoon Surface Composition and Preparation Method for Oxygen Nanobubbles for Drug Delivery and Ultrasound Imaging Applications |
title | Surface Composition and Preparation Method for Oxygen Nanobubbles for Drug Delivery and Ultrasound Imaging Applications |
title_full | Surface Composition and Preparation Method for Oxygen Nanobubbles for Drug Delivery and Ultrasound Imaging Applications |
title_fullStr | Surface Composition and Preparation Method for Oxygen Nanobubbles for Drug Delivery and Ultrasound Imaging Applications |
title_full_unstemmed | Surface Composition and Preparation Method for Oxygen Nanobubbles for Drug Delivery and Ultrasound Imaging Applications |
title_short | Surface Composition and Preparation Method for Oxygen Nanobubbles for Drug Delivery and Ultrasound Imaging Applications |
title_sort | surface composition and preparation method for oxygen nanobubbles for drug delivery and ultrasound imaging applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358755/ https://www.ncbi.nlm.nih.gov/pubmed/30609703 http://dx.doi.org/10.3390/nano9010048 |
work_keys_str_mv | AT khanmuhammadsaad surfacecompositionandpreparationmethodforoxygennanobubblesfordrugdeliveryandultrasoundimagingapplications AT hwangjangsun surfacecompositionandpreparationmethodforoxygennanobubblesfordrugdeliveryandultrasoundimagingapplications AT leekyungwoo surfacecompositionandpreparationmethodforoxygennanobubblesfordrugdeliveryandultrasoundimagingapplications AT choiyonghyun surfacecompositionandpreparationmethodforoxygennanobubblesfordrugdeliveryandultrasoundimagingapplications AT jangjaehee surfacecompositionandpreparationmethodforoxygennanobubblesfordrugdeliveryandultrasoundimagingapplications AT kwonyejin surfacecompositionandpreparationmethodforoxygennanobubblesfordrugdeliveryandultrasoundimagingapplications AT hongjongwook surfacecompositionandpreparationmethodforoxygennanobubblesfordrugdeliveryandultrasoundimagingapplications AT choijonghoon surfacecompositionandpreparationmethodforoxygennanobubblesfordrugdeliveryandultrasoundimagingapplications |