Cargando…

Active Compounds Derived from Fuzheng Huayu Formula Protect Hepatic Parenchymal Cells from Apoptosis Based on Network Pharmacology and Transcriptomic Analysis

Fuzheng huayu formula (FZHY), an antifibrotic traditional Chinese medicine, is frequently used for the treatment of liver fibrosis. In this study, network analysis, transcriptomic analysis, assays of cell apoptosis, viability and protein expression were used for investigating the effects and mechani...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Rong, Dong, Shu, Cai, Fei-Fei, Chen, Xiao-Le, Yang, Meng-Die, Liu, Ping, Su, Shi-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358846/ https://www.ncbi.nlm.nih.gov/pubmed/30669350 http://dx.doi.org/10.3390/molecules24020338

Ejemplares similares

Antiliver Fibrosis Formula of Fuzheng Huayu Alleviates Inflammatory Response
por: Chang, Qing-Qi, et al.
Publicado: (2022)

Effect of Fuzheng Huayu formula and its actions against liver fibrosis
por: Liu, Chenghai, et al.
Publicado: (2009)

Pharmacological mechanisms of Fuzheng Huayu formula for Aristolochic acid I–induced kidney fibrosis through network pharmacology
por: Wang, Fan, et al.
Publicado: (2022)

The Active Components of Fuzheng Huayu Formula and Their Potential Mechanism of Action in Inhibiting the Hepatic Stellate Cells Viability – A Network Pharmacology and Transcriptomics Approach
por: Xing, Xinrui, et al.
Publicado: (2018)

Dynamical Regulation Analysis Identifies Molecular Mechanisms of Fuzheng-Huayu Formula against Hepatitis B-Caused Liver Cirrhosis
por: Chen, Qi-Long, et al.
Publicado: (2015)

Curative Effects of Fuzheng Huayu on Liver Fibrosis and Cirrhosis: A Meta-Analysis
por: Dong, Shu, et al.
Publicado: (2015)

Effect of Fuzheng Huayu capsule combined with Pegasys on genotype 1 hepatitis C fibrosis and cell apoptosis
por: ZHANG, BO, et al.
Publicado: (2014)

Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF-α induced hepatocyte apoptosis
por: Tao, Yan-yan, et al.
Publicado: (2014)

Fuzheng Huayu recipe prevents nutritional fibrosing steatohepatitis in mice
por: Jia, Yan-Hong, et al.
Publicado: (2012)

Fuzheng Huayu Capsule Attenuates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate Cells
por: Wu, Mei, et al.
Publicado: (2020)

Effects of Fuzheng Huayu recipe on entecavir pharmacokinetics in normal and dimethylnitrosamine-induced hepatic fibrosis rats
por: Yang, Tao, et al.
Publicado: (2019)

Efficacy and Safety of a Botanical Formula Fuzheng Huayu for Hepatic Fibrosis in Patients with CHC: Results of a Phase 2 Clinical Trial
por: Hassanein, Tarek, et al.
Publicado: (2022)

Proteomic Analysis of the Effect of Fuzheng Huayu Recipe on Fibrotic Liver in Rats
por: Xie, Hongdong, et al.
Publicado: (2013)

Adjuvant Fuzheng Huayu Capsule Reduces the Incidence of Hepatocellular Carcinoma in Patients with Hepatitis B-Caused Cirrhosis
por: Shi, Ke, et al.
Publicado: (2020)

Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice
por: Jiang, Chunyan, et al.
Publicado: (2020)

Transcriptional Profiling and miRNA-Target Network Analysis Identify Potential Biomarkers for Efficacy Evaluation of Fuzheng-Huayu Formula-Treated Hepatitis B Caused Liver Cirrhosis
por: Chen, Qilong, et al.
Publicado: (2016)

The components data of fuzheng huayu extracts, cordyceps sinensis mycelia polysaccharide, gypenosides and amygdalin
por: Liu, Wei, et al.
Publicado: (2019)

Histological Outcome of Fuzheng Huayu plus Entecavir Combination Therapy in Chronic Hepatitis B Patients with Significant Liver Fibrosis
por: Gui, Hong-Lian, et al.
Publicado: (2020)

In Vitro Antibacterial Experiment of Fuzheng Jiedu Huayu Decoction Against Multidrug-Resistant Pseudomonas aeruginosa
por: Xu, Hongri, et al.
Publicado: (2020)

Baseline metabolites could predict responders with hepatitis B virus-related liver fibrosis for entecavir or combined with FuzhengHuayu tablet
por: Dai, Yun-Kai, et al.
Publicado: (2023)

Curative Effects of ZHENG-Based Fuzheng-Huayu Tablet on Hepatitis B Caused Cirrhosis Related to CYP1A2 Genetic Polymorphism
por: Li, Qing-Ya, et al.
Publicado: (2013)

Fuzheng Huayu Recipe and its active compounds inhibited HBeAg production by promoting TOMM34 gene expression in HBV-infected hepatocytes
por: Xing, Lu, et al.
Publicado: (2022)

A Randomized Controlled Study of Fuzheng Huayu Capsule for Prevention of Esophageal Variceal Bleeding in Patients with Liver Cirrhosis
por: Gu, Jie, et al.
Publicado: (2013)

Deciphering the Pharmacological Mechanisms of the Huayu-Qiangshen-Tongbi Formula Through Integrating Network Pharmacology and In Vitro Pharmacological Investigation
por: Wang, Zihao, et al.
Publicado: (2019)

Cyp4a12-mediated retinol metabolism in stellate cells is the antihepatic fibrosis mechanism of the Chinese medicine Fuzheng Huayu recipe
por: Ping, Da-bing, et al.
Publicado: (2023)

Fuzheng Huayu Recipe Ameliorates Liver Fibrosis by Restoring Balance between Epithelial-to-Mesenchymal Transition and Mesenchymal-to-Epithelial Transition in Hepatic Stellate Cells
por: Pan, Qin, et al.
Publicado: (2015)

Simultaneous determination of eight analytes of Fuzheng Huayu recipe in beagle dog plasma by UHPLC–Q/exactive Orbitrap HRMS and its application to toxicokinetics
por: Wang, Yu‐Lin, et al.
Publicado: (2022)

Therapeutic Efficacy of Fuzheng-Huayu Tablet Based Traditional Chinese Medicine Syndrome Differentiation on Hepatitis-B-Caused Cirrhosis: A Multicenter Double-Blind Randomized Controlled Trail
por: Song, Ya-Nan, et al.
Publicado: (2013)

Modulation of IKKβ/NF-κB and TGF-β1/Smad via Fuzheng Huayu recipe involves in prevention of nutritional steatohepatitis and fibrosis in mice
por: Wang, Rong-Qi, et al.
Publicado: (2015)

Network pharmacology-based prediction of active compounds in the Wenyang Jiedu Huayu formula acting on acute-on-chronic liver failure with experimental support in vitro and in vivo
por: Tang, Dan, et al.
Publicado: (2022)

Corrigendum: Network pharmacology-based prediction of active compounds in Wenyang Jiedu Huayu formula acting on acute-on-chronic liver failure with experimental support in vitro and in vivo
por: Tang, Dan, et al.
Publicado: (2022)

Syndrome of liver depression and spleen deficiency is a primary TCM syndrome of response to entecavir + FuZheng HuaYu in patients with HBV-related liver fibrosis
por: Dai, Yun-kai, et al.
Publicado: (2023)

Mechanism of Xiezhuo Huayu Yiqi Tongluo Formula in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology, Molecular Docking, and In Vivo Experiments
por: Fan, Lifei, et al.
Publicado: (2023)

Subchronic toxicity of herbal compound “Jiedu Huayu” granules in rats
por: Wang, Minggang, et al.
Publicado: (2017)

Network Pharmacology Interpretation of Fuzheng–Jiedu Decoction against Colorectal Cancer
por: Shi, Hongshuo, et al.
Publicado: (2021)

Network Pharmacology Study and Experimental Validation of Yiqi Huayu Decoction Inducing Ferroptosis in Gastric Cancer
por: Song, Siyuan, et al.
Publicado: (2022)

Renoprotective Effect of Yiqi Yangyin Huayu Tongluo Formula against Diabetic Nephropathy in Diabetic Rats
por: Wang, Feng-li, et al.
Publicado: (2018)

Fuzheng Yiliu Formula Regulates Tumor Invasion and Metastasis through Inhibition of WAVE3 Expression
por: Chen, Wen-li, et al.
Publicado: (2021)

Fuzheng Huayu Recipe Prevented and Treated CCl4-Induced Mice Liver Fibrosis through Regulating Polarization and Chemotaxis of Intrahepatic Macrophages via CCL2 and CX3CL1
por: Zhang, Man, et al.
Publicado: (2020)

Study on Intervention Mechanism of Yiqi Huayu Jiedu Decoction on ARDS Based on Network Pharmacology
por: Liang, Xu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v5bsc32uj643valrfvqlv0l3i6