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Aurora A Protein Kinase: To the Centrosome and Beyond

Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of A...

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Autores principales: Magnaghi-Jaulin, Laura, Eot-Houllier, Grégory, Gallaud, Emmanuel, Giet, Régis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359016/
https://www.ncbi.nlm.nih.gov/pubmed/30650622
http://dx.doi.org/10.3390/biom9010028
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author Magnaghi-Jaulin, Laura
Eot-Houllier, Grégory
Gallaud, Emmanuel
Giet, Régis
author_facet Magnaghi-Jaulin, Laura
Eot-Houllier, Grégory
Gallaud, Emmanuel
Giet, Régis
author_sort Magnaghi-Jaulin, Laura
collection PubMed
description Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of Aurora A at centrosomes, the mitotic spindle, and, more recently, at mitotic centromeres. In this review, we will summarise the cytoskeletal rearrangements regulated by Aurora A during cell division. We will also discuss the recent discoveries showing that Aurora A also controls not only the dynamics of the cortical proteins but also regulates the centromeric proteins, revealing new roles for this kinase during cell division.
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spelling pubmed-63590162019-02-11 Aurora A Protein Kinase: To the Centrosome and Beyond Magnaghi-Jaulin, Laura Eot-Houllier, Grégory Gallaud, Emmanuel Giet, Régis Biomolecules Review Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of Aurora A at centrosomes, the mitotic spindle, and, more recently, at mitotic centromeres. In this review, we will summarise the cytoskeletal rearrangements regulated by Aurora A during cell division. We will also discuss the recent discoveries showing that Aurora A also controls not only the dynamics of the cortical proteins but also regulates the centromeric proteins, revealing new roles for this kinase during cell division. MDPI 2019-01-15 /pmc/articles/PMC6359016/ /pubmed/30650622 http://dx.doi.org/10.3390/biom9010028 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Magnaghi-Jaulin, Laura
Eot-Houllier, Grégory
Gallaud, Emmanuel
Giet, Régis
Aurora A Protein Kinase: To the Centrosome and Beyond
title Aurora A Protein Kinase: To the Centrosome and Beyond
title_full Aurora A Protein Kinase: To the Centrosome and Beyond
title_fullStr Aurora A Protein Kinase: To the Centrosome and Beyond
title_full_unstemmed Aurora A Protein Kinase: To the Centrosome and Beyond
title_short Aurora A Protein Kinase: To the Centrosome and Beyond
title_sort aurora a protein kinase: to the centrosome and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359016/
https://www.ncbi.nlm.nih.gov/pubmed/30650622
http://dx.doi.org/10.3390/biom9010028
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