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Aurora A Protein Kinase: To the Centrosome and Beyond
Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of A...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359016/ https://www.ncbi.nlm.nih.gov/pubmed/30650622 http://dx.doi.org/10.3390/biom9010028 |
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author | Magnaghi-Jaulin, Laura Eot-Houllier, Grégory Gallaud, Emmanuel Giet, Régis |
author_facet | Magnaghi-Jaulin, Laura Eot-Houllier, Grégory Gallaud, Emmanuel Giet, Régis |
author_sort | Magnaghi-Jaulin, Laura |
collection | PubMed |
description | Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of Aurora A at centrosomes, the mitotic spindle, and, more recently, at mitotic centromeres. In this review, we will summarise the cytoskeletal rearrangements regulated by Aurora A during cell division. We will also discuss the recent discoveries showing that Aurora A also controls not only the dynamics of the cortical proteins but also regulates the centromeric proteins, revealing new roles for this kinase during cell division. |
format | Online Article Text |
id | pubmed-6359016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63590162019-02-11 Aurora A Protein Kinase: To the Centrosome and Beyond Magnaghi-Jaulin, Laura Eot-Houllier, Grégory Gallaud, Emmanuel Giet, Régis Biomolecules Review Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of Aurora A at centrosomes, the mitotic spindle, and, more recently, at mitotic centromeres. In this review, we will summarise the cytoskeletal rearrangements regulated by Aurora A during cell division. We will also discuss the recent discoveries showing that Aurora A also controls not only the dynamics of the cortical proteins but also regulates the centromeric proteins, revealing new roles for this kinase during cell division. MDPI 2019-01-15 /pmc/articles/PMC6359016/ /pubmed/30650622 http://dx.doi.org/10.3390/biom9010028 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Magnaghi-Jaulin, Laura Eot-Houllier, Grégory Gallaud, Emmanuel Giet, Régis Aurora A Protein Kinase: To the Centrosome and Beyond |
title | Aurora A Protein Kinase: To the Centrosome and Beyond |
title_full | Aurora A Protein Kinase: To the Centrosome and Beyond |
title_fullStr | Aurora A Protein Kinase: To the Centrosome and Beyond |
title_full_unstemmed | Aurora A Protein Kinase: To the Centrosome and Beyond |
title_short | Aurora A Protein Kinase: To the Centrosome and Beyond |
title_sort | aurora a protein kinase: to the centrosome and beyond |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359016/ https://www.ncbi.nlm.nih.gov/pubmed/30650622 http://dx.doi.org/10.3390/biom9010028 |
work_keys_str_mv | AT magnaghijaulinlaura auroraaproteinkinasetothecentrosomeandbeyond AT eothoulliergregory auroraaproteinkinasetothecentrosomeandbeyond AT gallaudemmanuel auroraaproteinkinasetothecentrosomeandbeyond AT gietregis auroraaproteinkinasetothecentrosomeandbeyond |