Cargando…

Targeting the Hepatocyte Growth Factor and c-Met Signaling Axis in Bone Metastases

Bone metastasis is the terminal stage disease of prostate, breast, renal, and lung cancers, and currently no therapeutic approach effectively cures or prevents its progression to bone metastasis. One of the hurdles to the development of new drugs for bone metastasis is the complexity and heterogenei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Whang, Young Mi, Jung, Seung Pil, Kim, Meyoung-Kon, Chang, In Ho, Park, Serk In
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359064/ https://www.ncbi.nlm.nih.gov/pubmed/30658428 http://dx.doi.org/10.3390/ijms20020384

Ejemplares similares

The Hepatocyte Growth Factor (HGF)/Met Axis: A Neglected Target in the Treatment of Chronic Myeloproliferative Neoplasms?
por: Boissinot, Marjorie, et al.
Publicado: (2014)

Hepatocyte Growth Factor/C-Met Axis in Thyroid Cancer: From Diagnostic Biomarker to Therapeutic Target
por: Trovato, Maria, et al.
Publicado: (2017)

Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications
por: García-Vilas, Javier A, et al.
Publicado: (2018)

Hepatocyte Growth Factor/c-Met Signaling Is Required for β-Cell Regeneration
por: Alvarez-Perez, Juan Carlos, et al.
Publicado: (2014)

Functional and therapeutic relevance of hepatocyte growth factor/c‐MET signaling in synovial sarcoma
por: Imura, Yoshinori, et al.
Publicado: (2016)

Hepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment
por: Rothenberger, Natalie J., et al.
Publicado: (2017)

Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases
por: Buenrostro, Denise, et al.
Publicado: (2014)

Hepatocyte growth factor/MET in cancer progression and biomarker discovery
por: Matsumoto, Kunio, et al.
Publicado: (2017)

Does hepatocyte growth factor/c-Met signal play synergetic role in lung cancer?
por: Wang, Xiangdong, et al.
Publicado: (2010)

Emerging molecular targets in oncology: clinical potential of MET/hepatocyte growth-factor inhibitors
por: Smyth, Elizabeth C, et al.
Publicado: (2014)

Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102
por: Buchanan, Ian M, et al.
Publicado: (2011)

Ganglioside GD3 induces convergence and synergism of adhesion and hepatocyte growth factor/Met signals in melanomas
por: Furukawa, Keiko, et al.
Publicado: (2014)

Met inactivation by S-allylcysteine suppresses the migration and invasion of nasopharyngeal cancer cells induced by hepatocyte growth factor
por: Cho, Oyeon, et al.
Publicado: (2015)

MEK inhibition enhances efficacy of bacillus Calmette-Guérin on bladder cancer cells by reducing release of Toll-like receptor 2-activated antimicrobial peptides
por: Whang, Young Mi, et al.
Publicado: (2017)

c-Met expression in renal cell carcinoma with bone metastases
por: Silva Paiva, Rita, et al.
Publicado: (2020)

Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma
por: Johnson, Jennifer, et al.
Publicado: (2015)

Hepatocyte Growth Factor/c-Met Signaling in Regulating Urokinase Plasminogen Activator in Human Stomach Cancer: A Potential Therapeutic Target for Human Stomach Cancer
por: Lee, Kyung Hee, et al.
Publicado: (2006)

Disruption of Hepatocyte Growth Factor/c-Met Signaling Enhances Pancreatic β-Cell Death and Accelerates the Onset of Diabetes
por: Mellado-Gil, Jose, et al.
Publicado: (2011)

MET Gene Copy Number Alterations and Expression of MET and Hepatocyte Growth Factor Are Potential Biomarkers in Angiosarcomas and Undifferentiated Pleomorphic Sarcomas
por: Schmitz, Katja, et al.
Publicado: (2015)

Impact of MET inhibition on small‐cell lung cancer cells showing aberrant activation of the hepatocyte growth factor/MET pathway
por: Taniguchi, Hirokazu, et al.
Publicado: (2017)

Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros
Publicado: (1995)

The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment
por: Parikh, Rahul A, et al.
Publicado: (2014)

Editorial of Special Issue “New Aspects of the Hepatocyte Growth Factor/c-Met System”
por: Ricci, Giulia
Publicado: (2015)

Hepatocyte growth factor and the hepatocyte growth factor receptor signalling complex as targets in cancer therapies
por: Jiang, W.G.
Publicado: (2007)

Host-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction
por: Franke, Raimo, et al.
Publicado: (2008)

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells
Publicado: (1993)

D1398G Variant of MET Is Associated with Impaired Signaling of Hepatocyte Growth Factor in Alveolar Epithelial Cells and Lung Fibroblasts
por: Atanelishvili, Ilia, et al.
Publicado: (2016)

Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling
por: Duclos, Catherine M, et al.
Publicado: (2017)

A High Affinity Hepatocyte Growth Factor-binding Site in the Immunoglobulin-like Region of Met
por: Basilico, Cristina, et al.
Publicado: (2008)

Clinical significance of hepatocyte growth factor/c-Met expression in the assessment of gastric cancer progression
por: NOGUCHI, EIICHIRO, et al.
Publicado: (2015)

Enhanced Wild-Type MET Receptor Levels in Mouse Hepatocytes Attenuates Insulin-Mediated Signaling
por: Rada, Patricia, et al.
Publicado: (2022)

A Potential Mechanism of Tumor Progression during Systemic Infections Via the Hepatocyte Growth Factor (HGF)/c-Met Signaling Pathway
por: Tsujimoto, Hironori, et al.
Publicado: (2020)

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte
por: Cicchini, Carla, et al.
Publicado: (2015)

Associations between hepatocyte growth factor, c-Met, and basic fibroblast growth factor and survival in endometrial cancer patients
por: Felix, A S, et al.
Publicado: (2012)

Met-Independent Hepatocyte Growth Factor-mediated regulation of cell adhesion in human prostate cancer cells
por: Tate, Amanda, et al.
Publicado: (2006)

A Hepatocyte Growth Factor Receptor (Met)–Insulin Receptor hybrid governs hepatic glucose metabolism
por: Fafalios, Arlee, et al.
Publicado: (2011)

FISH and immunohistochemical status of the hepatocyte growth factor receptor (c-Met) in 184 invasive breast tumors
por: Carracedo, Alma, et al.
Publicado: (2009)

MACC1 induces metastasis in ovarian carcinoma by upregulating hepatocyte growth factor receptor c-MET
por: SHENG, XIU-JIE, et al.
Publicado: (2014)

The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment
por: Fu, Haiyan, et al.
Publicado: (2021)

Hepatocyte growth factor and soluble cMet levels in plasma are prognostic biomarkers of mortality in patients with severe acute kidney injury
por: Li, Lilin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0u57cec0thkejbmuc2f40jv0kc