Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity

Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A–E (1–5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data fro...

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Detalles Bibliográficos
Autores principales: Feng, Wei, Zhou, Yuan, Zhou, Ling-Yu, Kang, Li-Ying, Wang, Xiang, Li, Bao-Lin, Li, Qing, Niu, Li-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359121/
https://www.ncbi.nlm.nih.gov/pubmed/30658485
http://dx.doi.org/10.3390/molecules24020331
Descripción
Sumario:Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A–E (1–5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1–5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC(50) ranging from 5.9 to 33.9 μM compared to Cisplatin.

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