Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity

Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A–E (1–5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data fro...

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Detalles Bibliográficos
Autores principales: Feng, Wei, Zhou, Yuan, Zhou, Ling-Yu, Kang, Li-Ying, Wang, Xiang, Li, Bao-Lin, Li, Qing, Niu, Li-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359121/
https://www.ncbi.nlm.nih.gov/pubmed/30658485
http://dx.doi.org/10.3390/molecules24020331
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author Feng, Wei
Zhou, Yuan
Zhou, Ling-Yu
Kang, Li-Ying
Wang, Xiang
Li, Bao-Lin
Li, Qing
Niu, Li-Ying
author_facet Feng, Wei
Zhou, Yuan
Zhou, Ling-Yu
Kang, Li-Ying
Wang, Xiang
Li, Bao-Lin
Li, Qing
Niu, Li-Ying
author_sort Feng, Wei
collection PubMed
description Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A–E (1–5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1–5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC(50) ranging from 5.9 to 33.9 μM compared to Cisplatin.
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spelling pubmed-63591212019-02-06 Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity Feng, Wei Zhou, Yuan Zhou, Ling-Yu Kang, Li-Ying Wang, Xiang Li, Bao-Lin Li, Qing Niu, Li-Ying Molecules Article Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A–E (1–5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1–5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC(50) ranging from 5.9 to 33.9 μM compared to Cisplatin. MDPI 2019-01-17 /pmc/articles/PMC6359121/ /pubmed/30658485 http://dx.doi.org/10.3390/molecules24020331 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Feng, Wei
Zhou, Yuan
Zhou, Ling-Yu
Kang, Li-Ying
Wang, Xiang
Li, Bao-Lin
Li, Qing
Niu, Li-Ying
Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity
title Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity
title_full Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity
title_fullStr Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity
title_full_unstemmed Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity
title_short Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity
title_sort novel cucurbitane triterpenes from the tubers of hemsleya amabilis with their cytotoxic acitivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359121/
https://www.ncbi.nlm.nih.gov/pubmed/30658485
http://dx.doi.org/10.3390/molecules24020331
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